Herbal medicines against bacterial vaginosis in women of reproductive age: A systematic review

Najafi, M. N. and Rezaee, R. and Najafi, N. N. and Mirzaee, F. and Burykina, T. I. and Lupuliasa, D. and Arsene, A. L. and Ghazanfarpour, M. (2019) Herbal medicines against bacterial vaginosis in women of reproductive age: A systematic review. Farmacia, 67 (6). pp. 931-940.

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Abstract

The aim of this systematic review was to present the effect of herbal medicines on both clinical symptoms and laboratory findings of bacterial vaginosis in the reproductive age. Four major databases (PubMed, Scopus, ISI Web of Science, and Cochrane Library) were systematically searched for articles that evaluated the effect of herbal medicines on bacterial vaginosis and were published until July 31, 2019. Zataria multiflora was found to be as effective as oral or vaginal metronidazole in improvement of both clinical symptoms and laboratory parameters. However, it caused vaginal irritation and burning. The effect of garlic tablet was reported to be more marked than oral metronidazole in alleviating the clinical symptoms and comparable to that of oral metronidazole in improving laboratory findings. The effect of Nigella sativa was similar to metronidazole in treating both clinical symptoms and laboratory findings. Hypericum perforatum vaginal gel 3 has proved to be as effective as metronidazole vaginal gel 0.75 in preventing bacterial vaginosis. Cure rate (recovery) in Myrtus communis L. plus metronidazole or Berberis vulgaris plus metronidazole was higher than that of metronidazole alone. Treatment with Hypercum perforatum for a week was very well tolerated, and caused no side effect. Herbal medicines including H. perforatum, Z. multiflora, B. vulgaris and Allium sativum was found to be as effective as metronidazole with a fewer side effect. Hence, they might be considered potential candidates to combat vaginosis. © 2019, Romanian Society for Pharmaceutical Sciences. All rights reserved.

Item Type: Article
Additional Information: Export Date: 16 February 2020 CODEN: FRMBA Correspondence Address: Ghazanfarpour, M.; Nursing Research Centre, Kerman University of Medical SciencesIran; email: Masoumeh.Ghazanfarpour@yahoo.com
Uncontrolled Keywords: Allium sativum B Bacterial vaginosis Gardnerella vaginalis H Herbal medicine Medicinal plants Multiflora Nigella sativa Perforatum Vulgaris Z Foeniculum vulgare extract garlic extract Hypericum perforatum extract metronidazole micosin Myrtus communis extract Nigella sativa extract pepper extract phytovagex Tribulus terrestris extract application site irritation Bacteroides fragilis Bacteroides thetaiotaomicron black cumin Calendula officinalis Clostridioides difficile Clostridium perfringens drug efficacy drug tolerability female human plant Prangos ferulacea Review Saugella lavanda side effect Staphylococcus aureus Staphylococcus epidermidis systematic review vaginal burning sensation vaginitis Zataria multiflora
Subjects: WQ Obstetrics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 09:26
Last Modified: 21 Jun 2020 09:26
URI: http://eprints.mums.ac.ir/id/eprint/18560

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