Review of antimicrobial peptides with anti-Helicobacter pylori activity

Neshani, A. and Zare, H. and Akbari Eidgahi, M. R. and Hooshyar Chichaklu, A. and Movaqar, A. and Ghazvini, K. (2019) Review of antimicrobial peptides with anti-Helicobacter pylori activity. Helicobacter, 24 (1).

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Background: The emergence of antibiotic-resistant Helicobacter pylori strains in recent years has increased the need for finding an alternative in the post-antibiotic era. One of the fields being considered for this purpose is antimicrobial peptides. The aim of this review was to provide an obvious scheme from the studied anti-H. pylori peptides and to investigate their common features. Method: First, all of the antimicrobial peptides with their anti-H. pylori effects have been proved up to September 2018 were selected and their information including structure, mechanism of action, and function was reviewed. To achieve this, three databases of PubMed, Scopus, and Web of science were used. Results: A total of 9 groups containing 22 antimicrobial peptides were found with demonstrated anti-H. pylori effects. The nine groups included pexiganan, tilapia piscidins, epinecidin-1, cathelicidins, defensins, bicarinalin, odorranain-HP, PGLa-AM1, and bacteriocins. Most of the antimicrobial peptides, not all, had common features such as the ability to kill antibiotic-resistant strains, having α-helical structure, being cationic, with high positive charge and isoelectric point. Conclusion: Antimicrobial peptides with anti-H. pylori effects have the potential to replace the antibiotics, especially in the post-antibiotic era, if a rapid and low-cost production method would be found. © 2018 John Wiley & Sons Ltd

Item Type: Article
Additional Information: Cited By :10 Export Date: 16 February 2020 CODEN: HELIF Correspondence Address: Ghazvini, K.; Antimicrobial Resistance Research Center, Mashhad University of Medical SciencesIran; email:
Uncontrolled Keywords: antimicrobial peptide Helicobacter pylori resistance treatment bacteriocin bicarinalin cathelicidin defensin epinecidin 1 human neutrophil peptide 1 odorranain hp pediocin peptide glycine leucine amide am1 pexiganan polypeptide antibiotic agent solyc tilapia piscidin unclassified drug antiinfective agent antimicrobial cationic peptide antibiotic resistance bacterial strain data base drug cost drug effect drug efficacy drug mechanism drug response drug structure Helicobacter infection priority journal Review treatment outcome animal chemistry human isolation and purification microbial sensitivity test Animals Anti-Bacterial Agents Anti-Infective Agents Antimicrobial Cationic Peptides Drug Resistance, Bacterial Helicobacter Infections Humans Microbial Sensitivity Tests
Subjects: QW Microbiology and Immunology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 09:30
Last Modified: 21 Jun 2020 09:30

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