Comparison of the neuroprotective effects of aspirin, atorvastatin, captopril and metformin in diabetes mellitus

Paseban, M. and Mohebbati, R. and Niazmand, S. and Sathyapalan, T. and Sahebkar, A. (2019) Comparison of the neuroprotective effects of aspirin, atorvastatin, captopril and metformin in diabetes mellitus. Biomolecules, 9 (4).

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Abstract

Objective: The aim of this study was to investigate the effect of combined intake of a high dose of aspirin, atorvastatin, captopril and metformin on oxidative stress in the brain cortex and hippocampus of streptozotocin (STZ)-induced diabetic rats. Material and methods: Rats were randomly divided into the following 11 groups: control and diabetic (D), as well as 9 groups that were treated with metformin (M, 300 mg/kg) or aspirin (ASA, 120 mg/kg) alone or in different combinations with captopril (C, 50 mg/kg) and/or atorvastatin (AT, 40 mg/kg) as follows: (D + M), (D + ASA), (D + M + ASA), (D + M + C), (D + M + AT), (D + M + C + ASA), (D + M + C + AT), (D + M + AT + ASA) and (D + M + C + AT + ASA). The rats in treatment groups received drugs by gavage daily for six weeks. Serum lipid profile and levels of oxidative markers in the brain cortex and hippocampus tissues were evaluated. Results: The levels of malondialdehyde in the brain cortex and hippocampus in all the treated groups decreased significantly (p < 0.05). There was a significant increase in the total thiol concentration as well as catalase activity in treated rats in (M + AT), (M + C + ASA), (M + C + AT), (M + AT + ASA) and (M + C + AT + ASA) groups in cortex and hippocampus in comparison with the diabetic rats (p < 0.05). Also, the superoxide dismutase activity in all treated rats with medications was significantly increased compared to the diabetic rats (p < 0.05–0.01). Conclusion: Our findings showed that the combined use of high-dose aspirin, metformin, captopril and atorvastatin potentiated their antioxidant effects on the brain, and hence could potentially improve cognitive function with their neuroprotective effects on hippocampus. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.

Item Type: Article
Additional Information: Cited By :3 Export Date: 16 February 2020 Correspondence Address: Niazmand, S.; Department of Physiology, School of Medicine, Mashhad University of Medical SciencesIran; email: niazmands@mums.ac.ir
Uncontrolled Keywords: Aspirin Atorvastatin Captopril Diabetes Metformin Neuroprotective Oxidative stress acetylsalicylic acid catalase cholesterol glucose high density lipoprotein cholesterol low density lipoprotein cholesterol malonaldehyde superoxide dismutase thiol triacylglycerol antidiabetic agent neuroprotective agent streptozocin adult animal experiment animal model animal tissue antidiabetic activity antioxidant activity Article brain cortex cognition controlled study diabetes mellitus drug megadose enzyme activity enzyme linked immunosorbent assay glucose blood level hippocampus lipid peroxidation male neuroprotection nonhuman rat streptozotocin-induced diabetes mellitus animal chemically induced comparative study experimental diabetes mellitus Wistar rat Animals Diabetes Mellitus, Experimental Hypoglycemic Agents Neuroprotective Agents Rats Rats, Wistar
Subjects: QT physiology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 21 Jun 2020 09:36
Last Modified: 21 Jun 2020 09:36
URI: http://eprints.mums.ac.ir/id/eprint/18583

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