The role of fibromodulin in cancer pathogenesis: Implications for diagnosis and therapy

Pourhanifeh, M. H. and Mohammadi, R. and Noruzi, S. and Hosseini, S. A. and Fanoudi, S. and Mohamadi, Y. and Hashemzehi, M. and Asemi, Z. and Mirzaei, H. R. and Salarinia, R. and Mirzaei, H. (2019) The role of fibromodulin in cancer pathogenesis: Implications for diagnosis and therapy. Cancer Cell International, 19 (1).

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Abstract

Fibromodulin (FMOD) is known as one of very important extracellular matrix small leucine-rich proteoglycans. This small leucine-rich proteoglycan has critical roles in the extracellular matrix organization and necessary for repairing of tissue in many organs. Given that the major task of FMOD is the modulation of collagen fibrillogenesis. However, recently observed that FMOD plays very important roles in the modulation of a variety of pivotal biological processes including angiogenesis, regulation of TGF-β activity, and differentiation of human fibroblasts into pluripotent cells, inflammatory mechanisms, apoptosis and metastatic related phenotypes. Besides these roles, FMOD has been considered as a new tumor-related antigen in some malignancies such as lymphoma, leukemia, and leiomyoma. Taken together, these findings proposed that FMOD could be introduced as diagnostic and therapeutic biomarkers in treatment of various cancers. Herein, for first time, we highlighted the various roles of FMOD in the cancerous conditions. Moreover, we summarized the diagnostic and therapeutic applications of FMOD in cancer therapy. © 2019 The Author(s).

Item Type: Article
Additional Information: Cited By :3 Export Date: 16 February 2020 CODEN: CCIAC Correspondence Address: Salarinia, R.; Department of Medical Biotechnology and Molecular Sciences, School of Medicine, North Khorasan University of Medical SciencesIran; email: R.salarinia@nkums.ac.ir
Uncontrolled Keywords: Cancer Diagnosis Fibromodulin Therapy integrin transforming growth factor beta apoptosis cancer diagnosis cancer growth cancer prognosis cancer therapy carboxy terminal sequence carcinogenesis cell migration disease association epithelial mesenchymal transition extracellular matrix human nonhuman protein function protein targeting Review tumor microenvironment tumor vascularization
Subjects: WH Hemic and Lymphatic System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 27 Jun 2020 05:24
Last Modified: 27 Jun 2020 05:24
URI: http://eprints.mums.ac.ir/id/eprint/18593

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