Genetic polymorphisms and epigenetic regulation of survivin encoding gene, BIRC5, in multiple sclerosis patients

Rahban, D. and Mohammadi, F. and Alidadi, M. and Ghantabpour, T. and Kheyli, P. A. G. and Ahmadi, M. (2019) Genetic polymorphisms and epigenetic regulation of survivin encoding gene, BIRC5, in multiple sclerosis patients. BMC Immunology, 20 (1).

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Abstract

Background: The persistent the inflammatory condition in multiple sclerosis (MS) may due to the aberrant regulation of the elimination of the pathogenic autoreactive lymphocytes through apoptosis. Survivin, encoded by the BIRC5 gene, has been indicated to be involved in the regulation of apoptosis. This survey intended to investigate the genetic and microRNA mediated regulation of survivin in relapsing-remitting MS (RRMS) disease. Results: It was observed that the C allele (OR = 1.38, 95 CI = 1.05-1.348, P = 0.022) and CC genotype (OR = 1.84, 95 CI = 1.06-3.19; P = 0.029) in the rs9904341 polymorphism increased the disease risk. Furthermore, miR-34a was significantly downregulated (Fold change = 0.41, P = 0.001) in the PBMCs from RRMS subjects. Survivin mRNA expression in PBMCs and serum survivin level were increased in RRMS patients in comparison to the controls. Downregulation of miR-34a was negatively correlated with increased survivin level. Conclusion: Although the genetic polymorphism of BIRC5 gene was associated with the disease risk, miR-34a was suggested to be involved in the regulation of survivin in the RRMS patients. © 2019 The Author(s).

Item Type: Article
Additional Information: Export Date: 16 February 2020 CODEN: BIMMC Correspondence Address: Rahban, D.; Department of Nanomedicine, School of Advanced Medical Technologies, Tehran University of Medical SciencesIran; email: rahbandariush@gmail.com
Uncontrolled Keywords: Apoptosis BIRC5 gene microRNA Multiple sclerosis Survivin complementary DNA microRNA 34a allele Article case control study controlled study disease activity DNA synthesis down regulation epigenetics Expanded Disability Status Scale gene gene frequency genetic code genetic polymorphism genetic risk genetic variation genotype human lymphocyte major clinical study pathogenicity peripheral blood mononuclear cell protein blood level protein expression single nucleotide polymorphism
Subjects: WT Geriatrics . Chronic Diseases
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 27 Jun 2020 05:28
Last Modified: 27 Jun 2020 05:28
URI: http://eprints.mums.ac.ir/id/eprint/18597

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