Poly (methacrylic acid-co-acrylic acid)-grafted polyvinylpyrrolidone coated Magnetic nanoparticles as a pH-responsive magnetic Nano-carrier for controlled delivery of antibiotics

Amoli-Diva, Mitra and Pourghazi, Kamyar (2017) Poly (methacrylic acid-co-acrylic acid)-grafted polyvinylpyrrolidone coated Magnetic nanoparticles as a pH-responsive magnetic Nano-carrier for controlled delivery of antibiotics. Nanomedicine Journal, 4 (1). pp. 25-36.

[img]
Preview
Text
NMJ_Volume 4_Issue 1_Pages 25-36.pdf

Download (2MB) | Preview
Official URL: http://nmj.mums.ac.ir/article_8049.html

Abstract

Objective(s): Pharmaceutical industries are leading to improved medications that can target diseases more effectively and precisely. Researchers have intended to reformulate drugs so that they may be more safely used in human body. The more targeted a drug is, the lower its chance of triggering drug resistance, a cautionary concern surrounding the use of broad-spectrum antibiotics. The aim of this paper is to introduce efficient drug delivery vehicles which can perform both targeted and controlled antibiotic release by synthesis of magnetic pH-responsive polymer. Materials and Methods: Iron oxide nanoparticles were synthesized by chemical co-precipitation technique and primary coated with 3-trimethoxysilylpropylamine (APTS). APTS coated MNPs was used in the reaction medium for synthesis of a pH-responsive poly (MAA-co-AAc)-grafted PVP. The prepared vehicle was characterized by TEM, XRD, FT-IR, TGA, DSC and elemental analysis. Drug loading, release, kinetics and mechanism of the system were evaluated.Results: The results for drug release showed that the release of antibiotics in pH 5.5 and 7.2 could be effectively sustained, while about 92 of the drugs were released at pH 1.2. Considerations demonstrate the tendency of drug release by Fickian mechanism and diffusion controlled release.Conclusion: The results indicate that the prepared magnetic nano-carrier could be suitable for site-specific antibiotic delivery through oral administration.

Item Type: Article
Subjects: QT physiology
Divisions: Journals > Nanomedicine Journal
Depositing User: nmj nmj
Date Deposited: 20 Sep 2017 15:17
Last Modified: 20 Sep 2017 15:17
URI: http://eprints.mums.ac.ir/id/eprint/1860

Actions (login required)

View Item View Item