The screening of renoprotective agents by99mTc-DMSA: A review of preclinical studies

Rezaei, M. and Papie, M. and Cheki, M. and Mansi, L. and Kitson, S. and Ahmadi, A. (2019) The screening of renoprotective agents by99mTc-DMSA: A review of preclinical studies. Current Radiopharmaceuticals, 12 (3). pp. 211-219.

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Abstract

Background: Nephrotoxicity is a prevalent consequence of cancer treatment using radiotherapy and chemotherapy or their combination. There are two methods; histological and biochemical, to assess the kidney damage caused by toxic agents in animal studies. Although these methods are used for the try-out of renoprotective factors, these methods are invasive and time-consuming, and also, lack the necessary sensitivity for primary diagnosis. Quantitative renal99mTc-DMSA scintigraphy is a noninvasive, precise and sensitive radionuclide technique which is used to assess the extent of kidney damage, so that the extent of injury to the kidney will be indicated by the renal uptake rate of99mTc-DMSA in the kidney. In addition, this scintigraphy evaluates the effect of the toxic agents by quantifying the alterations in the biodistribution of the radiopharmaceutical. Conclusion: In this review, the recent findings about the renoprotective agents were evaluated and screened with respect to the use of99mTc-DMSA, which is preclinically and clinically used for animal cases and cancer patients under the treatment by radiotherapy and chemotherapy. © 2019 Bentham Science Publishers.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Cheki, M.; Cancer Research Center, Ahvaz Jundishapur University of Medical SciencesIran; email: mohsencheky@gmail.com
Uncontrolled Keywords: 99mTc-DMSA Cisplatin Gentamicin Ionizing radiation Nephrotoxicity Renoprotective agents agmatine amifostine carnitine erdosteine erythropoietin succimer tc 99m thymol bioaccumulation clinical effectiveness drug effect drug efficacy drug mechanism drug response drug screening follow up glomerulus filtration rate human kidney perfusion kidney size kidney tubule absorption nonhuman preclinical study priority journal radiation dose radioactivity renal protection Review
Subjects: WB Practice of Medicine
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 27 Jun 2020 05:29
Last Modified: 27 Jun 2020 05:29
URI: http://eprints.mums.ac.ir/id/eprint/18612

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