Frequency of tox`ocariasis among asthmatic children in northeastern Iran

Shamsian, S. A. and Sayedi, S. J. and Zibaei, M. and Vaghei, S. and Moghaddas, E. (2019) Frequency of tox`ocariasis among asthmatic children in northeastern Iran. Archives of Clinical Infectious Diseases, 14 (6).

[img] Text
Frequency of tox`ocariasis among asthmatic children in northeastern Iran.pdf

Download (610kB)


Background: Toxocariasis is a zoonotic and telluric disease caused by the Toxocara species mostly in tropical areas. The relationship between toxocariasis and asthma has always been a subject of discussion. Objectives: This study evaluated the seroepidemiology of Toxocara among asthmatic children. Methods: This cross-sectional study evaluated 150 children aged 3-12 years with asthma presentations, who were referred to Dr. Sheikh Hospital of Mashhad University of Medical Sciences from April 2017 to March 2018. Serum samples were tested for the presence of anti-Toxocara antibodies using Enzyme-linked Immunosorbent assay (ELISA). Positive sera were confirmed by the Western Blotting (WB) method. Results: Out of 150 asthmatic patients, Toxocara immunoglobulin G (IgG) antibody responses were observed in two (1.3) patients by ELISA and one (0.6) patient by both ELISA and WB. Moreover, none of the patients was detected as hypereosinophilia. Conclusions: It seems there is no significant relationship between Toxocara infection and asthma in Northeastern Iran. These findings suggest the need for WB immunodiagnosis and ELISA using Toxocara antigens to improve human toxocariasis diagnosis in patients with asthma. © 2019, Archives of Clinical Infectious Diseases.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Moghaddas, E.; Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical SciencesIran; email:
Uncontrolled Keywords: Antibody Asthma Children ELISA Toxocara Western Blotting immunoglobulin G antibody response Article child enzyme linked immunosorbent assay eosinophil count human hypereosinophilia Iran morbidity preschool child questionnaire risk factor school child sensitivity and specificity toxocariasis
Subjects: QX Parasitology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 27 Jun 2020 05:36
Last Modified: 27 Jun 2020 05:36

Actions (login required)

View Item View Item