Diagnosis of acute toxoplasmosis by igg and igm antibodies and igg avidity in pregnant women from Mashhad, eastern Iran

Sharifi, K. and Hosseini Farash, B. R. and Tara, F. and Khaledi, A. and Sharifi, K. and Shamsian, S. A. A. (2019) Diagnosis of acute toxoplasmosis by igg and igm antibodies and igg avidity in pregnant women from Mashhad, eastern Iran. Iranian Journal of Parasitology, 14 (4). pp. 639-645.

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Background: We aimed to evaluate the diagnosis of acute toxoplasmosis by IgG avidity test in pregnant women. Methods: In this cross-sectional study, 250 blood samples were collected from pregnant women with the first month of their pregnancy referring to health centers of University in Mashhad during 2016. Samples were centrifuged at 3000 rpm for 5 min for separation of serum and were kept in the-20 until use. To detection of acute and chronic toxoplasmosis, anti-Toxoplasma antibodies (IgG and IgM, and IgG avidity tests were performed using ELISA. Then, data analyzed using SPSS software by Frequency, Pearson Chi-Square, Likelihood Ratio, and Exact tests. And P<0.05 was statistically considered as significant. Results: Total prevalence of IgG and IgM was 23.2 and 7.2, respectively. A significant correlation was observed between the mean age and IgG level (P<0.05). It was not found any correlation between the history of raw meat consumption, cats keeping, education, and residency site. Moreover, 16 people (6.4) had IgM antibody, of which, 10 cases (62.5) with low avidity for IgG and 1 people (6.2) with moderate avidity and 5 cases (31.3) with high avidity for IgG. Moreover, 76 of pregnant women were seronegative. Conclusion: More than half of the women (62.5) with positive IgM antibody in their serum had a low avidity for IgG which revealed an acute infection among pregnant women. Toxoplasma infection should be considered as an important factor that affects the pregnancy and IgG avidity as an important test for screening the women who need the treatment. © 2019, Tehran University of Medical Sciences (TUMS). All rights reserved.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Shamsian, S.A.A.; Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical SciencesIran; email: shamsianaa@mums.ac.ir
Uncontrolled Keywords: IgG avidity Iran Pregnant women Toxoplasmosis immunoglobulin G immunoglobulin M adult agammaglobulinemia antibody titer Article binding affinity controlled study cross-sectional study enzyme linked immunosorbent assay female human immunosuppressive treatment kidney transplantation Leishmania infantum major clinical study optical density pregnant woman prevalence questionnaire Relative Avidity Index risk factor sensitivity and specificity seroprevalence
Subjects: WQ Obstetrics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 27 Jun 2020 05:36
Last Modified: 27 Jun 2020 05:36
URI: http://eprints.mums.ac.ir/id/eprint/18643

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