Role of the transforming growth factor-β signaling pathway in the pathogenesis of colorectal cancer

Soleimani, A. and Pashirzad, M. and Avan, A. and Ferns, G. A. and Khazaei, M. and Hassanian, S. M. (2019) Role of the transforming growth factor-β signaling pathway in the pathogenesis of colorectal cancer. Journal of Cellular Biochemistry, 120 (6). pp. 8899-8907.

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Abstract

The transforming growth factor-β (TGF-β) signaling pathway plays an important role in cancer cell proliferation, growth, metastasis, and apoptosis. It has been shown that TGF-β acts as a tumor suppressor in the early stages of the disease, and as a tumor promoter in its late stages. Mutations in the TGF-β signaling components, the TGF-β receptors and cytoplasmic signaling transducers, are frequently observed in colorectal carcinomas. Exploiting specific TGF-β receptor agonist and antagonist with antitumor properties may be a way of controlling cancer progression. This review summarizes the regulatory role of TGF-β signaling in the pathogenesis of colorectal cancer. © 2018 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: Cited By :6 Export Date: 16 February 2020 CODEN: JCEBD Correspondence Address: Hassanian, S.M.; Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical SciencesIran; email: hasanianmehrm@mums.ac.ir
Uncontrolled Keywords: colorectal cancer transforming growth factor-β receptors transforming growth factor-β signaling transforming growth factor beta Article cancer growth cancer resistance carcinogenesis human nonhuman pathogenesis priority journal signal transduction
Subjects: QU Biochemistry
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 27 Jun 2020 05:59
Last Modified: 27 Jun 2020 05:59
URI: http://eprints.mums.ac.ir/id/eprint/18657

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