Protective effects of aminoguanidine against sodium metavanadate-induced spatial memory retention impairment in Morris water maze

Tabrizian, K. and Esmaeilei, M. and Hashemzaei, M. and Esmaeilzaei, A. and Fanoudi, S. and Sanati, M. and Belaran, M. and Rigi, M. and Bazi, A. and Anvari, N. and Rezaee, R. (2019) Protective effects of aminoguanidine against sodium metavanadate-induced spatial memory retention impairment in Morris water maze. Pharmaceutical Sciences, 25 (2). pp. 93-99.

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Abstract

Background: Vanadium is a potential neurotoxic agent widely distributed in the environment. Understanding the neurotoxic mechanisms of vanadium on learning and memory seems necessary. Methods: We investigated the time-dependent (1-week, 2- week and 4-week) effects of sodium metavanadate (SMV) (25 mg/kg/day; pre-training oral administration) and 4-day intraperitoneal injections of aminoguanidine (AG) as a selective inducible nitric oxide synthase inhibitor (10, 50, and 100 mg/kg) on spatial memory retention in Morris water maze. Animals were trained for 4 days and tested 48 h after the last training trial. Results: The data showed that 4-week oral pre-treatment with SMV (25 mg/kg/day) induced spatial memory retention deficits and decreased the time spent in the target quadrant. We found that 4-day administration of different doses of AG during training trials significantly decreased the time and distance of finding the hidden platforms. Additionally, SMV-induced spatial memory retention impairments were prevented in animals received combined SMV (25 mg/kg/day, 4 weeks) and AG (10 mg/kg/day, 4 days). Conclusion: Our findings showed the protective role of AG on SMV-induced spatial memory retention deficits. © 2019 The Authors.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Fanoudi, S.; Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical SciencesIran; email: fanoudis921@mums.ac.ir
Uncontrolled Keywords: Inducible Nitric Oxide ynthase Morris water maze Sodium metavanadate Spatial memory aminoguanidine vanadate sodium animal experiment animal model animal tissue Article controlled study dose response drug effect escape latency male memory consolidation memory disorder Morris water maze test neuroprotection nonhuman rat swimming speed time
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 27 Jun 2020 05:40
Last Modified: 27 Jun 2020 05:40
URI: http://eprints.mums.ac.ir/id/eprint/18664

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