Prevalence of CCR5delta32 in Northeastern Iran

Tajbakhsh, A. and Fazeli, M. and Rezaee, M. and Ghasemi, F. and Heravi, M. M. and Gholoobi, A. and Meshkat, Z. (2019) Prevalence of CCR5delta32 in Northeastern Iran. BMC Medical Genetics, 20 (1).

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Abstract

Background: A 32-base pair deletion (32) in the open reading frame (ORF) of C-C motif chemokine receptor 5 (CCR5) seems to be a protective variant against immune system diseases, especially human immunodeficiency virus type 1 (HIV-1). We aimed to assess the frequency of CCR5 32 in the healthy Iranian population. Methods: In this study, 400 normal samples from Khorasan, northeastern Iran, were randomly selected. The frequency of CCR5 32 carriers was investigated using PCR analysis. Allele prevalence and the fit to the Hardy-Weinberg equilibrium were analyzed. Results: The prevalence of CCR5 32 in the northeastern population of Iran was 0.016. Four hundred samples were studied, among which one with CCR5 32/32 and 11 with CCR5 Wild/32 genotype were detected. Conclusion: This study was the first investigation for an assessment of the prevalence of CCR5 32 in northeastern Iran. The low prevalence of CCR5 32 allele in the Iranian population may result in the increased susceptibility to HIV-1. In addition, this prevalence is the same as that of reported in East Asia, while is lower than that in the Europeans. © 2019 The Author(s).

Item Type: Article
Additional Information: Export Date: 16 February 2020 CODEN: BMGMA Correspondence Address: Meshkat, Z.; Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, P.O Box: 9196773117, Iran; email: meshkatz@mums.ac.ir
Uncontrolled Keywords: CC chemokine receptor type 5 (CCR5) Epidemiology Geographic spread HIV-1 Rare alleles adult allele Article blood sampling CCR5delta32 gene cohort analysis female gene genotype human Human immunodeficiency virus 1 infection infection sensitivity Iran Iranian people male middle aged normal human polymerase chain reaction prevalence wild type
Subjects: W General medicine- Health professions
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 27 Jun 2020 05:33
Last Modified: 27 Jun 2020 05:33
URI: http://eprints.mums.ac.ir/id/eprint/18671

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