A case of D alloimmunization in pregnancy: Successfully treated solely with therapeutic plasma exchange (TPE)

Tara, F. and Maleki, A. and Taheri, N. and Darbari, S. M. (2019) A case of D alloimmunization in pregnancy: Successfully treated solely with therapeutic plasma exchange (TPE). Journal of Blood Medicine, 10. pp. 251-253.

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Abstract

One of the most common causes of fetal anemia is red cell alloimmunization. The standard treatment in fetuses with anemia is intrauterine transfusion (IUT); but this approach may have adverse effects, or sometimes it is not available or even possible. Therefore, immune modulating approaches such as therapeutic plasma exchange (TPE) and the use of intravenous immunoglobulin should be implemented to avoid or delay IUT. We report here the successful management of a case of D alloimmunization in pregnancy solely with TPE, without the need for IUT. The patient was a 33-year-old G4, L2, and D1, who had a history of alloimmunization in her previous pregnancy. TPE was initiated at 17 weeks gestation and was repeated weekly. Altogether, 20 times of plasma exchange were performed and a normal fetus was delivered at week 37. © 2019 Tara et al.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Maleki, A.; Department of Obstetrics and Gynecology, Mashhad University of Medical SciencesIran; email: Malekiaa@mums.ac.ir
Uncontrolled Keywords: Alloimmunization Hemolytic disease of the newborn Therapeutic plasma exchange adult Apgar score Article case report cesarean section clinical article Coombs test doppler sonography echography female fetus distress fetus echography fetus hydrops human infant male peak systolic velocity plasma exchange preeclampsia pregnancy
Subjects: WQ Obstetrics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 27 Jun 2020 05:42
Last Modified: 27 Jun 2020 05:42
URI: http://eprints.mums.ac.ir/id/eprint/18673

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