The relation between zero-time pretransplant deceased donor renal biopsy and kidney transplant survival

Tavakkoli, M. and Yousefi, M. and Mahdavi, R. and Kalantari, M. R. and Mirsani, A. and Korooji, A. (2019) The relation between zero-time pretransplant deceased donor renal biopsy and kidney transplant survival. Research and Reports in Urology, 11. pp. 123-130.

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Abstract

Introduction: There are several investigations about preimplantation biopsy results in alive donors. However, assessment of the biopsies in deceased donors’ kidney and its correlation with patient survival is limited. In this study, we evaluated the correlation between zero-time pretransplant kidney biopsy and survival of kidney in deceased donors. Patients and methods: This was a cohort study conducted at Montaserieh Hospital, Mashhad, between January 2016 and December 2017. We included all brain dead patients who were referred to Montaserieh transplantation center. After vascular anastomosis of kidneys in recipient patients, in the operation room, and de-clumping of vessels, biopsies were taken from upper pole of donated kidney. Blocks of biopsies were evaluated by expert pathologists and then reported. We followed patients for 1 year and compared the pathologic findings and renal survival in them. Results: The mean age of deceased donors was 32.32±1.49 years and that of the recipient patients was 36.33±1.27 years. Thirty-eight recipient patients (45.2) were female and 46 were male (54.8). The most pathologic pattern in our study was grade I separation, followed by blebs, dilatation, and loss of attenuation. We showed that most of the transplantations were safe after 1-year follow-up (85.7) without any complications. We observed thrombosis in two cases (2.4) and rejection of transplantation in ten patients (11.9). Cox regression analysis showed that end-stage renal disease grade (HR =3.84, 95 CI =2.315-6.348; P<0.0001) and gender of the deceased donors (HR =0.34, 95 CI =0.145-0.797; P=0.013) were related to graft survival rate. Conclusion: Only cast feature in pathologic exam was related to graft survival, which is a marker of tissue ischemia. There was no significant correlation between other histological findings and graft survival. © 2019 Tavakkoli et al.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Yousefi, M.; Department of Urology, Ghaem Hospital, Shariati Square, Ebn-e-Sina Street, Post box 1339, Iran; email: drmyousefi1@yahoo.com
Uncontrolled Keywords: Deceased donors Graft outcome Kidney Renal biopsy Survival rate Transplant adult allergic glomerulonephritis arteriosclerosis Article blood vessel shunt brain dead donor clinical article cohort analysis controlled study deceased donor end stage renal disease female gender glomerulosclerosis glomerulus filtration rate graft recipient graft survival human human tissue hypoxia ischemia kidney biopsy kidney polycystic disease male thrombosis transplantation conditioning vesicoureteral reflux
Subjects: WJ Urogenital System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 27 Jun 2020 05:59
Last Modified: 27 Jun 2020 05:59
URI: http://eprints.mums.ac.ir/id/eprint/18676

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