Bacteriotherapy in breast cancer

Yaghoubi, A. and Khazaei, M. and Hasanian, S. M. and Avan, A. and Cho, W. C. and Soleimanpour, S. (2019) Bacteriotherapy in breast cancer. International Journal of Molecular Sciences, 20 (23).

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Breast cancer is the second most common cause of cancer-related mortality among women around the world. Conventional treatments in the fight against breast cancer, such as chemotherapy, are being challenged regarding their effectiveness. Thus, strategies for the treatment of breast cancer need to be continuously refined to achieve a better patient outcome. We know that a number of bacteria are pathogenic and some are even associated with tumor development, however, recent studies have demonstrated interesting results suggesting some bacteria may have potential for cancer therapy. Therefore, the therapeutic role of bacteria has aroused attention in medical and pharmaceutical studies. Furthermore, genetic engineering has been used in bacterial therapy and may led to greater efficacy with few side effects. Some genetically modified non-pathogenic bacterial species are more successful due to their selectivity for cancer cells but with low toxicity for normal cells. Some live, attenuated, or genetically modified bacterias are capable to multiply in tumors and inhibit their growth. This article aims to review the role of bacteria and their products including bacterial peptides, bacteriocins, and toxins for the treatment of breast cancer. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 Correspondence Address: Cho, W.C.; Department of Clinical Oncology, Queen Elizabeth HospitalHong Kong; email:
Uncontrolled Keywords: Bacterial peptide Bacteriocins Bacteriotherapy Breast cancer Toxin azurin bacteriocin botulinum toxin A bovicin cytotoxin diphtheria toxin entap exotoxin exotoxin a exotoxin t hyaluronidase laterosporulin 10 nisin ohmyungsamycin a ohmyungsamycin b polypeptide antibiotic agent proximicin signal peptide toll like receptor agonist tumor antigen unclassified drug urukthapelstatin a Actinomycetales antineoplastic activity Bifidobacterium longum colon cancer colorectal carcinoma cytotoxic T lymphocyte dendritic cell Enterococcus human Lactobacillus Listeria monocytogenes liver cancer liver cell carcinoma lung cancer non muscle invasive bladder cancer nonhuman Pseudomonas aeruginosa Review Salmonella enterica serovar Typhimurium stomach cancer Streptomyces Verrucosispora
Subjects: WQ Obstetrics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 27 Jun 2020 05:47
Last Modified: 27 Jun 2020 05:47

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