The major molecular mechanisms mediating the renoprotective effects of SGLT2 inhibitors: An update

Yaribeygi, H. and Simental-Mendía, L. E. and Banach, M. and Bo, S. and Sahebkar, A. (2019) The major molecular mechanisms mediating the renoprotective effects of SGLT2 inhibitors: An update. Biomedicine and Pharmacotherapy, 120.

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Abstract

The incidence of diabetes mellitus, as well as its complications, is rapidly growing. Diabetic nephropathy is one of the most prevalent disorders induced by chronic uncontrolled hyperglycemia and is accompanied by a reduction in renal sufficiency with microstructural tissue damage in the kidneys. Many therapeutic protocols have been designed to address the treatment and prevention of diabetic nephropathy. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are a newly introduced class of glucose-lowering agents that reduce blood glucose by inhibition of urinary glucose reabsorption in renal proximal tubules and so induce glycosuria. Also, these hypoglycemic agents may provide protective effects in different tissues such as cardiovascular, brain, and kidneys. In recent years, accumulating evidence has indicated that SGLT2i possess potent renal protective properties in the setting of diabetes. In the current study, we present the latest findings regarding the renoprotective effects of SGLT2 inhibition and discuss the molecular mechanisms involved. © 2019 The Authors

Item Type: Article
Additional Information: Export Date: 16 February 2020 CODEN: BIPHE Correspondence Address: Sahebkar, A.; Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, P.O. Box: 91779-48564, Iran; email: sahebkara@mums.ac.ir
Uncontrolled Keywords: Diabetic nephropathy Hemodynamic changes Interleukins Kidney Oxidative stress SGLT2 natriuretic factor sodium glucose cotransporter 2 inhibitor uric acid blood pressure variability body weight loss diabetes mellitus drug mechanism glycemic control human kidney fibrosis pathophysiology priority journal renal protection Review sodium absorption uric acid blood level
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 27 Jun 2020 05:43
Last Modified: 27 Jun 2020 05:43
URI: http://eprints.mums.ac.ir/id/eprint/18689

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