Sentinel Node Biopsy in Urothelial Carcinoma of the Bladder: Systematic Review and Meta-Analysis

Zarifmahmoudi, L. and Ghorbani, H. and Sadri, K. and Tavakkoli, M. and Keshvari, M. and Salehi, M. and Sadeghi, R. (2019) Sentinel Node Biopsy in Urothelial Carcinoma of the Bladder: Systematic Review and Meta-Analysis. Urologia Internationalis, 103 (4). pp. 373-382.

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Objectives: To determine the application of sentinel node biopsy in urothelial carcinoma of the bladder, we performed a systematic review and meta-analysis. Methods: Pooled false negative rate and detection rate were presented using Meta-Disc (version 1.4), and comprehensive meta-analysis (version 2). Publication bias and heterogeneity were assessed using funnel plot, Cochrane Q test, and I2 index. Results: The pooled detection rate was 91 (95 CI 87-93) and pooled sensitivity was 79 (95 CI 0.69-0.86). When the neoadjuvant chemotherapy group of patients was omitted, the pooled sensitivity changed to 82 (95 CI 74-88), and the Cochrane Q and I2 statistics were 15.44 and 48.2, respectively. The pooled sensitivity of studies that included > 50 of pT 3 or 4 patients was 70 (59-80), by omitting studies that enrolled > 50 of patients at pT stage of 3 or 4, the pooled sensitivity increased to 93 (81-98). Conclusions: Although the studies on SN biopsy of muscle invasive bladder cancer patients resulted in a high detection rate and sensitivity, further validated multicenter trials with larger sample size are essential to confirm the reliability and accuracy of this approach and obtain a standardized method. We showed that pT1 or pT2 bladder cancer patients with clinically negative lymph nodes are the most appropriated group for sentinel lymph node mapping. © 2019 S. Karger AG, Basel. Copyright: All rights reserved

Item Type: Article
Additional Information: Export Date: 16 February 2020 CODEN: URINA Correspondence Address: Sadeghi, R.; Nuclear Medicine Research Center, Mashhad University of Medical SciencesIran; email:
Uncontrolled Keywords: Bladder Cancer Sentinel lymph mode tracer cancer diagnosis computer assisted tomography cystectomy diagnostic test accuracy study diagnostic value false negative result human lymphoscintigraphy meta analysis muscle invasive bladder cancer neoadjuvant chemotherapy nuclear magnetic resonance imaging pelvis lymphadenectomy priority journal Review sensitivity analysis sentinel lymph node biopsy systematic review transitional cell carcinoma
Subjects: WJ Urogenital System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib1 lib1
Date Deposited: 27 Jun 2020 05:47
Last Modified: 27 Jun 2020 05:47

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