2-Substituent Synthesis of 5-3- Methoxyphenyl and 5-4- Methoxyphenyl-1, 3, 4-Oxadiazoles, 2-Yl-Pyridine- 2-Yl-Methanol in Positions of 2 and 3 of 1, 3, 4-Oxadiazoles Containing Halogen and the Evaluation of Their Antibacterial Properties

Sarveahrabi, Yasin and Souldozi, Ali and Talebi, Reza (2020) 2-Substituent Synthesis of 5-3- Methoxyphenyl and 5-4- Methoxyphenyl-1, 3, 4-Oxadiazoles, 2-Yl-Pyridine- 2-Yl-Methanol in Positions of 2 and 3 of 1, 3, 4-Oxadiazoles Containing Halogen and the Evaluation of Their Antibacterial Properties. Navid No, 22 (72). pp. 1-13.

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Abstract

Introduction: The emergence of drug resistance in microorganisms poses a serious threat to human health; therefore, new oxadiazole derivatives can be a good alternative. In this regard, the present study aimed to evaluate the antibacterial activity of the synthesized oxadiazole derivatives and compare it with conventional antibacterial drugs. Materials and Methods: In the current study, following the one-step reaction process, new derivatives of oxadiazoles were obtained with the 1, 3, 4-oxadiazole isomer. Thereafter, they were confirmed by InfraRed )IR), Nuclear Magnetic Resonance)C-NMR), and Hydrogen Nuclear Magnetic Resonance)  H-NMR spectroscopy). Antibacterial activity of derivatives was established by performing a test and re-test on Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, Pseudomonas aeruginosa, and Escherichia coli. using disc diffusion method, determination of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) at a concentration of 1 mg/ml. Results: As evidenced by the obtained results, the compounds synthesized at 1 mg/ml had antibacterial effects on Staphylococcus aureus and Staphylococcus epidermidis. However, they exerted no effect on the other bacteria which were tested.   Conclusion: The results of the current study indicated that the new single-step oxadiazole derivatives have a very good antibacterial activity against Gram-positive bacteria.

Item Type: Article
Uncontrolled Keywords: Antibacterial activity,Oxadiazole,Staphylococcus aureus,Staphylococcus epidermidis
Subjects: QW Microbiology and Immunology
QX Parasitology
Divisions: Journals > Navid No
Depositing User: nnj nnj
Date Deposited: 18 Apr 2020 16:44
Last Modified: 18 Apr 2020 16:44
URI: http://eprints.mums.ac.ir/id/eprint/18701

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