Assessment of interferon-γ levels and leishmanin skin test results in persons recovered for leishmaniasis

Alimohammadian, M. H. and Jones, S. L. and Darabi, H. and Riazirad, F. and Ajdary, S. and Shabani, A. and Rezaee, M. A. and Mohebali, M. and Hosseini, Z. and Modabber, F. (2012) Assessment of interferon-γ levels and leishmanin skin test results in persons recovered for leishmaniasis. American Journal of Tropical Medicine and Hygiene, 87 (1). pp. 70-75.

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Patients who recover from leishmaniasis usually show development of strong immunity and induction of interferon-γ (IFN-γ) and delayed type hypersensitivity. In a randomized trial, we analyzed the IFN-γ response by using a Quantiferon-Leishmania assay against three Leishmania peptide antigens and compared it with results of the leishmanin skin test (LST) in persons residing in areas in Iran to which zoonotic cutaneous leishmaniasis (ZCL, 181 persons), anthroponotic cutaneous leishmaniasis (ACL, 104 persons), and zoonotic visceral leishmaniasis (ZVL, 67 persons) are endemic. The percentage of persons with an IFN-γ-positive response (> 0.2 IU/mL) to three antigens and the mean concentration of IFN-γ induced by the antigens were higher for persons from areas endemic for ZVL than for persons from areas endemic for ZCL and ACL. The percentage of persons with LST-positive results (≥ 5 mm indurations) was 99, 94, and 70 for areas with ZCL, ACL, and ZVL, respectively. Our data indicate that the LST is significantly more sensitive than IFN-γ levels in persons who have been cured of cutaneous leishmaniasis than in persons who have been cured of ZVL. Copyright © 2012 by The American Society of Tropical Medicine and Hygiene.

Item Type: Article
Additional Information: Cited By :10 Export Date: 16 February 2020 CODEN: AJTHA Correspondence Address: Alimohammadian, M.H.; Immunology Department, Pasteur Institute of Iran, Pasteur Avenue, Tehran, Iran; email:
Uncontrolled Keywords: antigen gamma interferon protozoal protein adolescent adult aged article controlled study endemic disease female human information processing Iran leishmanin skin test major clinical study male protein blood level randomized controlled trial sensitivity analysis skin leishmaniasis statistical significance visceral leishmaniasis Antigens, Protozoan Endemic Diseases Enzyme-Linked Immunosorbent Assay Humans Interferon-gamma Leishmaniasis Middle Aged Skin Tests Young Adult
Subjects: QX Parasitology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 03 May 2020 04:48
Last Modified: 03 May 2020 04:48

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