Comparison of COX2 expression between oral squamous cell carcinoma, leukoplakia and normal mucosa

Amirchaghmaghi, M. and Mohtasham, N. and Mozaffari, P. M. (2012) Comparison of COX2 expression between oral squamous cell carcinoma, leukoplakia and normal mucosa. Journal of Contemporary Dental Practice, 13 (2). pp. 205-209.

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Aim: To compare cyclooxygenase 2 expression (COX2-E) between normal, oral leukoplakia lesions and different grades of oral squamous cell carcinoma (SCC). Materials and methods: Around 90 paraffin embedded blocks consisting of 45 SCC, 15 leukoplakia and 17 controls were selected for immunohistochemistry (IHC) for detection of COX2-E. COX2-E was divided in four grades, as A (0-10), B (11-40), C (41-70) and D (> 70) cellularity. Results: Mean age of the patients was 55.17 ± 18.41 (M:57.92 ± 16.87, F:52.19 ± 19.74). A significant difference was found in COX2 expression between SCC total and, basal and spinous layers of leukoplakia (p < 0.05). COX2-E in spinous layer of normal tissue was significantly lower than SCC (p = 0.000). COX2-E was significantly different in SCC grade 3 and leukoplakia (p = 0.001) and normal tissue (p = 0.000). COX2-E was significantly higher in SCC grade 3 compared to leukoplakia (basal layer) (p = 0.000). Conclusion: We showed a significant higher COX2-E in SCC lesions compared to leukoplakias and normal controls. In our study COX2-E was not significantly different in SCC grades 1, 2 and 3 (p > 0.05).

Item Type: Article
Additional Information: Cited By :5 Export Date: 16 February 2020 Correspondence Address: Mohtasham, N.; Department of Oral Pathology, Oral and Maxillofacial Diseases Research Center, Faculty of Dentistry, Mashhad University of Medical Sciences, Vakil Abad Blv, AzadiSQR, PO Box: 984, Mashhad Khorasan Razavi Province, Postal Code: 91735, Iran; email:
Uncontrolled Keywords: Cyclooxygenase 2 Expression Head and neck cancer Leukoplakia Oral cancer
Subjects: WU Dentistry. Oral surgery
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 03 May 2020 09:19
Last Modified: 03 May 2020 09:19

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