Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazole

Anaeigoudari, A. and Shafei, M. N. and Soukhtanloo, M. and Sadeghnia, H. R. and Reisi, P. and Beheshti, F. and Mohebbati, R. and Mousavi, S. M. and Hosseini, M. (2015) Lipopolysaccharide-induced memory impairment in rats is preventable using 7-nitroindazole. Arquivos de Neuro-Psiquiatria, 73 (9). pp. 784-790.

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Inflammation and oxidative stress have important roles in memory impairment. The effect of 7-nitroindazole (7NI) on lipopolysaccharide (LPS)-induced memory impairment was investigated. Rats were used, divided into four groups that were treated as follows: (1) control (saline); (2) LPS; (3) 7NI-LPS; and (4) 7NI before passive avoidance (PA). In the LPS group, the latency for entering the dark compartment was shorter than in the controls (p < 0.01 and p < 0.001); while in the 7NI-LPS group, it was longer than in the LPS group (p < 0.01 and p < 0.001). Malondialdehyde (MDA) and nitric oxide (NO) metabolite concentrations in the brain tissues of the LPS group were higher than in the controls (p < 0.001 and p < 0.05); while in the 7NI-LPS group, they were lower than in the LPS group (p < 0.001 and p < 0.05, respectively). The thiol content in the brain of the LPS group was lower than in the controls (p < 0.001); while in the 7NI-LPS group, it was higher than in the LPS group (p < 0.001). It is suggested that brain tissue oxidative damage and NO elevation have a role in the deleterious effects of LPS on memory retention that are preventable using 7NI. © 2015, Associacao Arquivos de Neuro-Psiquiatria. All rights reserved.

Item Type: Article
Additional Information: Cited By :17 Export Date: 16 February 2020 CODEN: ANPIA Correspondence Address: Hosseini, M.; Neurocognitive Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical SciencesIran; email:
Uncontrolled Keywords: 7NI Learning Lipopolysaccharide Memory 7 nitroindazole malonaldehyde nitric oxide superoxide dismutase thiol derivative 7-nitroindazole indazole derivative neuroprotective agent animal experiment animal model animal tissue Article brain tissue chemical reaction colorimetry controlled study enzyme activity latent period light related phenomena male memory disorder microplate reader nonhuman passive avoidance test rat animal brain chemistry chemically induced drug effects Memory Disorders Wistar rat Animals Indazoles Lipopolysaccharides Neuroprotective Agents Rats Rats, Wistar
Subjects: WM Psychiatry
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 09 May 2020 09:31
Last Modified: 09 May 2020 09:31

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