Diagnostic accuracy of fluorine-18-fluorodeoxyglucose positron emission tomography in gallbladder cancer: A meta-analysis

Annunziata, S. and Pizzuto, D. A. and Caldarella, C. and Galiandro, F. and Sadeghi, R. and Treglia, G. (2015) Diagnostic accuracy of fluorine-18-fluorodeoxyglucose positron emission tomography in gallbladder cancer: A meta-analysis. World Journal of Gastroenterology, 21 (40). pp. 11481-11488.

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AIM: To meta-analyze published data about the diagnostic accuracy of fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and PET/computed tomography (PET/CT) in the evaluation of primary tumor in patients with gallbladder cancer (GBCa). METHODS: A comprehensive literature search of studies published through 30th June 2014 regarding the role of 18F-FDG PET and PET/CT in the evaluation of primary gallbladder cancer (GBCa) was performed. All retrieved studies were reviewed. Pooled sensitivity and specificity of 18F-FDG PET or PET/CT in the evaluation of primary GBCa were calculated. The area under the summary receiving operator characteristics curve (AUC) was calculated to measure the accuracy of these methods. Sub-analyses considering the device used (PET vs PET/CT) were carried out. RESULTS: Twenty-one studies comprising 495 patients who underwent 18F-FDG PET or PET/CT for suspicious GBCa were selected for the systematic review. The meta-analysis of 13 selected studies provided the following results: sensitivity 87 (95CI: 82-92), specificity 78 (95CI: 68-86). The AUC was 0.88. Improvement of sensitivity and specificity was observed when PET/CT was used. CONCLUSION: 18F-FDG-PET and PET/CT demonstrated to be useful diagnostic imaging methods in the assessment of primary tumor in GBCa patients, nevertheless possible sources of false-negative and false-positive results should be kept in mind. PET/CT seems to have a better diagnostic accuracy than PET alone in this setting. © 2015 Baishideng Publishing Group Inc. All rights reserved.

Item Type: Article
Additional Information: Cited By :8 Export Date: 16 February 2020 CODEN: WJGAF Correspondence Address: Annunziata, S.; Department of Bioimaging and Radiological Sciences, Institute of Nuclear Medicine, Catholic University of Sacred HeartItaly; email: salvatoreannunziata@live.it
Uncontrolled Keywords: Fluorine- 18-fluorodeoxyglucose Gallbladder cancer Positron emission tomography Positron emission tomography/computed tomography fluorodeoxyglucose f 18 radiopharmaceutical agent area under the curve Article cancer diagnosis computer assisted emission tomography diagnostic accuracy diagnostic test accuracy study false negative result false positive result human meta analysis PET scanner PET-CT scanner receiver operating characteristic sensitivity and specificity systematic review diagnostic imaging gallbladder tumor multimodal imaging predictive value reproducibility x-ray computed tomography Fluorodeoxyglucose F18 Gallbladder Neoplasms Humans Positron-Emission Tomography Predictive Value of Tests Radiopharmaceuticals Reproducibility of Results Tomography, X-Ray Computed
Subjects: WI Digestive System
WN Radiology . Diagnostic Imaging
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 04 May 2020 06:47
Last Modified: 04 May 2020 06:47
URI: http://eprints.mums.ac.ir/id/eprint/18753

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