A clinical trial of neoadjuvant concurrent chemoradiotherapy followed by resection for esophageal carcinoma

Anvari, K. and Aledavood, S. A. and Toussi, M. S. and Forghani, M. N. and Mohtashami, S. and Rajabi, M. T. and Shandiz, F. H. and Nosrati, F. and Nowferesti, G. and Salek, R. (2015) A clinical trial of neoadjuvant concurrent chemoradiotherapy followed by resection for esophageal carcinoma. Journal of Research in Medical Sciences, 20 (8). pp. 751-756.

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Background: Esophageal carcinoma is a common malignancy in the North East of Iran. Combined modality treatments have been adopted to improve survival in patients with esophageal carcinoma. In this trial, we evaluated the efficacy and toxicity of a preoperative concurrent chemoradiotherapy protocol in the patients with locally advanced esophageal carcinoma. Materials and Methods: Between 2006 and 2011, eligible patients with locally advanced esophageal carcinoma underwent concurrent radiotherapy and chemotherapy and 3-4 weeks later, esophagectomy. Pathologic response, overall survival rate, toxicity, and feasibility were evaluated. Results: One hundred ninety-seven patients with a median age of 59 (range: 27-70) entered the protocol. One hundred ninety-four cases (98.5) had esophageal squamous cell carcinoma. Grades 3-4 of toxicity in patients undergoing neoadjuvant chemoradotherapy were as follows: Neutropenia in 21 and esophagitis in 2.5 of cases. There were 11 (5.6) early death probably due to the treatment-related toxicities. One hundred twenty-seven patients underwent surgery with postsurgical mortality of 11. In these cases, the complete pathological response was shown in 38 cases (29.9) with a 5-year overall survival rates of 48.2 and median overall survival of 44 months (95 confidence interval, 24.46-63.54). Conclusion: The pathological response rate and the overall survival rate are promising in patients who completed the protocol as receiving at least one cycle of chemotherapy. However, the treatment toxicities were relatively high. © 2015 Journal of Research in Medical Sciences.

Item Type: Article
Additional Information: Cited By :7 Export Date: 16 February 2020 Correspondence Address: Aledavood, S.A.; Cancer Research Center, Mashhad University of Medical SciencesIran; email: aledavooda@mums.ac.ir
Uncontrolled Keywords: Esophageal carcinoma Neoadjuvant chemoradiation Survival cisplatin fluorouracil adjuvant chemoradiotherapy adult aged Article atelectasis cancer surgery chylothorax clinical trial death dysphagia esophagitis esophagus carcinoma esophagus resection female fistula human liver metastasis major clinical study male nausea neutropenia overall survival pneumonia treatment outcome vomiting
Subjects: QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 11 May 2020 06:14
Last Modified: 11 May 2020 06:14
URI: http://eprints.mums.ac.ir/id/eprint/18754

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