Deletion of Ovarian Hormones Induces a Sickness Behavior in Rats Comparable to the Effect of Lipopolysaccharide

Azizi-Malekabadi, H. and Hosseini, M. and Pourganji, M. and Zabihi, H. and Saeedjalali, M. and Anaeigoudari, A. (2015) Deletion of Ovarian Hormones Induces a Sickness Behavior in Rats Comparable to the Effect of Lipopolysaccharide. Neurology Research International, 2015.

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Neuroimmune factors have been proposed as the contributors to the pathogenesis of sickness behaviors. The effects of female gonadal hormones on both neuroinflammation and depression have also been well considered. In the present study, the capability of deletion of ovarian hormones to induce sickness-like behaviors in rats was compared with the effect lipopolysaccharide (LPS). The groups were including Sham, OVX, Sham-LPS, and OVX-LPS. The Sham-LPS and OVX-LPS groups were treated with LPS (250 μg/kg) two hours before conducting the behavioral tests. In the forced swimming (FST), the immobility times in both OVX and Sham-LPS groups were higher than that of Sham (P < 0.001). In open-field (OP) test, the central crossing number by OVX and Sham-LPS groups were lower than Sham (P < 0.001) while there were no significant differences between OVX-LPS and OVX groups. In elevated plus maze (EPM), the percent of entries to the open arm by both OVX and Sham-LPS groups was lower than that of Sham group (P < 0.001). The results of present study showed that deletion of ovarian hormones induced sickness behaviors in rats which were comparable to the effects of LPS. Moreover, further investigations are required in order to better understand the mechanism(s) involved. © 2015 Hamid Azizi-Malekabadi et al.

Item Type: Article
Additional Information: Cited By :10 Export Date: 16 February 2020 Correspondence Address: Hosseini, M.; Neurocognitive Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Azadi Square, Iran; email:
Uncontrolled Keywords: lipopolysaccharide animal experiment animal model Article behavioral research comparative study controlled study elevated plus maze test female forced swim test gene deletion hormone deficiency illness behavior nonhuman open field test ovary priority journal rat sham procedure
Subjects: WM Psychiatry
WP Gynecology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 04 May 2020 05:18
Last Modified: 04 May 2020 05:18

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