Different effects of scopolamine on learning, memory, and nitric oxide metabolite levels in hippocampal tissues of ovariectomized and sham-operated rats

Azizi-Malekabadi, H. and Hosseini, M. and Soukhtanloo, M. and Sadeghian, R. and Fereidoni, M. and Khodabandehloo, F. (2012) Different effects of scopolamine on learning, memory, and nitric oxide metabolite levels in hippocampal tissues of ovariectomized and sham-operated rats. Arquivos de Neuro-Psiquiatria, 70 (6). pp. 447-452.

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Abstract

Different effects of scopolamine on learning, memory, and nitric oxide (NO) metabolites in hippocampal tissues of ovariectomized (OVX) and sham-operated rats were investigated. The animals in the Sham-Scopolamine (Sham-Sco) and OVX-Scopolamine (OVX-Sco) Groups were treated with 2 mg/kg scopolamine before undergoing the Morris water maze, while the animals in the Sham and OVX Groups received saline. The time latency and path length were significantly higher in both the Sham-Sco and the OVX-Sco Groups, in comparison with the Sham and OVX Groups, respectively (p<0.001). Significantly lower NO metabolite levels in the hippocampi of the Sham-Sco Group were observed, compared with the Sham Group (p<0.001), while there was no significant difference between the OVX-Sco and OVX Groups. The decreased NO level in the hippocampus may play a role in the learning and memory deficits induced by scopolamine. However, it seems that the effect of scopolamine on hippocampal NO differs between situations of presence and absence of ovarian hormones.

Item Type: Article
Additional Information: Cited By :33 Export Date: 16 February 2020 CODEN: ANPIA Correspondence Address: Hosseini, M.; Neuroscience Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; email: hosseinim@MUMS.ac.ir
Uncontrolled Keywords: Hippocampus Morris water maze Nitric oxide Ovariectomized Rat Scopolamine animal experiment animal tissue article biochemistry blood sampling cognitive defect concentration (parameters) controlled study drug effect experimental test female learning memory nonhuman ovariectomy sham procedure Animals Cholinergic Antagonists Maze Learning Rats Rats, Wistar Reaction Time Scopolamine Hydrobromide Time Factors
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 04 May 2020 07:52
Last Modified: 04 May 2020 07:52
URI: http://eprints.mums.ac.ir/id/eprint/18770

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