Effects of pentoxifylline on non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled trial in Iran

Baniasadi, N. and Salajegheh, F. and Pardakhty, A. and Seyedmirzaee, S. M. and Hayatbakhsh, M. M. and Nikpoor, A. R. and Mohammadi, M. (2015) Effects of pentoxifylline on non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled trial in Iran. Hepatitis Monthly, 15 (11).

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Abstract

Background: Non-alcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease. Several studies suggest that pentoxifylline (PTX) can improve the disease outcome. Objectives: We aimed to compare the effect of pentoxifylline with placebo on liver aminotransferases and cytokines, including interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), and interleukin 8 (IL-8) in patients with NASH. Patients and Methods: Thirty patients with NASH were included in the study, based on ultrasonography and 1.5-fold mean change from baseline serum levels of liver aminotransferases. Patients with NASH were randomized to receive 1200 mg PTX (the intervention group) or placebo (the placebo group) for 6 months. The serum levels of liver aminotransferases and cytokines were compared between the intervention and placebo groups, at various time points. Results: The serum levels of liver aminotransferases were significantly reduced at 3 months and at 6 months, compared with baseline, in both groups. The serum levels of IL-6 were significantly decreased, in both groups, only at 6 months, compared with baseline. Compared to the placebo group, the serum level of TNF-α was significantly decreased in the intervention group, at 6 months. The serum level of IL-8 was increased, in both groups, after 6 months, without reaching clinical significance. There was no significant difference in serum levels of liver aminotransferases and cytokines, between intervention and placebo groups. Conclusions: Decreases in the serum levels of liver aminotransferases and cytokines, in both groups, are related to low-calorie diets and exercise, rather than PTX. © 2015, Kowsar Corp.

Item Type: Article
Additional Information: Cited By :5 Export Date: 16 February 2020 Correspondence Address: Mohammadi, M.; Department of Immunology, School of Medicine, Mashhad University of Medical SciencesIran; email: mozhganmohammadi69@yahoo.co.uk
Uncontrolled Keywords: Clinical trial Cytokines Non-alcoholic fatty liver disease Pentoxifylline alanine aminotransferase aspartate aminotransferase interleukin 6 interleukin 8 placebo tumor necrosis factor alpha adult Article body mass clinical article controlled study double blind procedure echography enzyme linked immunosorbent assay female human Iran male nonalcoholic fatty liver randomized controlled trial
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 05 May 2020 06:12
Last Modified: 05 May 2020 06:12
URI: http://eprints.mums.ac.ir/id/eprint/18786

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