The effect of gabapentin on muscle cramps during hemodialysis: A double-blind clinical trial

Beladi Mousavi, S. S. and Zeraati, A. and Moradi, S. and Mousavi, M. B. (2015) The effect of gabapentin on muscle cramps during hemodialysis: A double-blind clinical trial. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 26 (6). pp. 1142-1148.

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Abstract

Hemodialysis-associated muscle cramps (HAMC) are a common complication during hemodialysis (HD) sessions. A number of pharmacologic agents have been evaluated to prevent and or diminish HAMC; however, none of them has an established role. To the best of our knowledge, this is the first study to evaluate the possible effect of gabapentin on HAMC. In a double-blinded clinical trial, we compared the possible effect of gabapentin with a placebo in prevention and or diminishing episodes of HAMC in HD patients who had experienced frequent intradialytic muscle cramps. At first, placebo was given before each dialysis session for four weeks and then, after a two-week washout period, 300 mg of gabapentin was given before each dialysis session for four weeks to verify the effect of gabapentin on HAMC. Overall, 15 patients (seven men and eight women; mean age, 52.02 years) with frequent intradialytic muscle cramps were enrolled in the study. The incidence of symptomatic muscle cramp decreased in the gabapentin group compared with the placebo group, with a significant difference between them (P = 0.001). The intensity of muscle cramps also decreased in the gabapentin group (P = 0.001). There was no significant association between HAMC in male and female patients (P = 0. 397), mean age of HD patients (P = 0.226) and cause of end-stage renal disease (P = 0.551). According to the results of our study, gabapentin prescription before each HD session significantly reduced the frequency and the intensity of muscle cramps during HD without any major side-effects.

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020
Uncontrolled Keywords: 4 aminobutyric acid amine anticonvulsive agent cyclohexanecarboxylic acid derivative gabapentin adverse effects clinical trial double blind procedure female human Kidney Failure, Chronic male middle aged muscle cramp renal replacement therapy Amines Anticonvulsants Cyclohexanecarboxylic Acids Double-Blind Method gamma-Aminobutyric Acid Humans Renal Dialysis
Subjects: WJ Urogenital System
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 12 May 2020 06:33
Last Modified: 12 May 2020 06:33
URI: http://eprints.mums.ac.ir/id/eprint/18795

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