Preventing and therapeutic effect of propolis in radiotherapy induced mucositis of head and neck cancers: A triple-blind, randomized, placebo-controlled trial

Bolouri, A. J. and Pakfetrat, A. and Tonkaboni, A. and Aledavood, S. A. and Najafi, M. F. and Delavarian, Z. and Shakeri, M. T. and Mohtashami, A. (2015) Preventing and therapeutic effect of propolis in radiotherapy induced mucositis of head and neck cancers: A triple-blind, randomized, placebo-controlled trial. International Journal of Cancer Management, 8 (5).

[img] Text
preventing and therapeutic effect of.pdf

Download (829kB)

Abstract

Background: Mucositis is one of the acute complications of radiotherapy which can ulcerate oral mucosa and cause severe pain and discomfort which can affect oral normal function. Propolis is a natural source of flavenoid which has antiulcer, antibacterial, antifungal, healing and anti-inflammatory effects. Using such an affordable compound without any bad smell or taste that has reasonable price can help the radiotherapy undergoing patients. Objectives: Our goal is assessing the preventing and therapeutic effect of propolis in radiotherapy induced mucositis in patients with head and neck cancer. Patients and Methods: In a randomized triple blind clinical trial, 20 patient were selected randomly to swish and swallow 15 ml of water based extract of propolis mouth wash 3 times a day in the case group (n = 10) and 15 ml placebo mouth wash in control group (n = 10). we use NIC-CTC scale for determining mucositis grading. Results: We use T-test, Man-Whitney, Chi-square, and Friedman as analyzing tests. Case group had significantly (P < 0.05) lower grade of mucositis in all of the follow-ups, but xerostomia is not significantly different in two groups (P > 0.05). Conclusions: This is a pilot study which shows water based extract of propolis efficiently prevents and heals radiotherapy induced mucositis. © 2015, Iranian Journal of Cancer Prevention.

Item Type: Article
Additional Information: Cited By :14 Export Date: 16 February 2020 Correspondence Address: Tonkaboni, A.; Department of Oral Medicine, School of Dentistry, Tehran University of Medical SciencesIran; email: a.tonkaboni@yahoo.com
Uncontrolled Keywords: Cancer Mouthwashes Mucositis Propolis Radiotherapy placebo adult Article cancer radiotherapy clinical article clinical effectiveness cobalt therapy controlled study drug efficacy female follow up head and neck cancer human male malnutrition mucosa inflammation pilot study radiation dose radiation injury radiation protection randomized controlled trial treatment outcome triple blind procedure weight reduction xerostomia
Subjects: WU Dentistry. Oral surgery
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 12 May 2020 05:35
Last Modified: 12 May 2020 05:35
URI: http://eprints.mums.ac.ir/id/eprint/18798

Actions (login required)

View Item View Item