Vitamin D receptor gene polymorphisms in type 1 diabetes mellitus: A new pattern from Khorasan province, Islamic Republic of Iran

Bonakdaran, S. and Abbaszadegan, M. R. and Dadkhah, E. and Khajeh-Dalouie, M. (2012) Vitamin D receptor gene polymorphisms in type 1 diabetes mellitus: A new pattern from Khorasan province, Islamic Republic of Iran. Eastern Mediterranean Health Journal, 18 (6). pp. 614-619.

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Abstract

Reported associations between vitamin D receptor (VDR) polymorphism and type 1 diabetes mellitus vary across ethnic groups. We studied the association between type 1 diabetes and 4 VDR gene polymorphisms (Bb, Ff, Aa and Tt) in an Iranian population. A group of 69 patients with type 1 diabetes mellitus and 45 unrelated healthy subjects were recruited. The prevalence of VDR polymorphisms in 4 restriction fragment length polymorphism sites including BsmI, FokI, ApaI and TaqI were analysed in patients and controls. The frequencies of 3 genotypes (Aa, FF and Bb) were significantly higher in the patient group. The relationship between VDR gene polymorphisms and onset pattern of diabetes was not significant. There were no significant difference between the genotype frequencies and chronic complications of diabetes, but the relationship between the Ff genotype and ketoacidosis was significant. Our results differ from previous polymorphism studies in other regions.

Item Type: Article
Additional Information: Cited By :20 Export Date: 16 February 2020 CODEN: EMHJA Correspondence Address: Abbaszadegan, M. R.; Division of Human Genetics, Immunology Research Centre, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran; email: abbaszadeganmr@mums.ac.ir
Uncontrolled Keywords: Article controlled study DNA polymorphism gene gene frequency genetic association genotype human insulin dependent diabetes mellitus Iran ketoacidosis major clinical study prevalence restriction fragment length polymorphism Vitamin D receptor gene
Subjects: WD Nutrition Disease and metabolic diseases
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 10 May 2020 18:06
Last Modified: 10 May 2020 18:06
URI: http://eprints.mums.ac.ir/id/eprint/18799

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