Effect of prenatal selenium supplementation on cord blood selenium and lipid profile

Boskabadi, H. and Maamouri, G. and Rezagholizade Omran, F. and Mafinejad, S. and Tara, F. and Rayman, M. P. and Ghayour-Mobarhan, M. and Sahebkar, A. and Tavallaie, S. and Shakeri, M. T. and Mohammadi, M. and Ferns, G. A. (2012) Effect of prenatal selenium supplementation on cord blood selenium and lipid profile. Pediatrics and Neonatology, 53 (6). pp. 334-339.

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Abstract

Background: Selenium is an essential trace element and as a component of selenoproteins it plays a key role as an antioxidant. We aimed to evaluate the effect of selenium supplementation during pregnancy on cord blood selenium content and lipid profile. Methods: This trial was performed on 166 eligible women who were randomized to receive 100 μg of selenium, as selenium-yeast (Se group) or a placebo-yeast tablet (placebo group). Umbilical cord blood samples were collected at the time of delivery and selenium concentration and lipid profile were measured. Results: Triglyceride levels were found to be significantly higher in the Se group than in the placebo group (p = 0.01). However, no significant difference in cord blood selenium was observed between the groups nor were there any significant correlations between cord blood selenium and lipid profile parameters. Conclusion: Our findings suggest that selenium supplementation in pregnant women may be associated with an increased cord-blood triglyceride level, although total cholesterol, low-density lipoprotein and high-density lipoprotein cholesterol levels did not change significantly. The clinical significance of the increased cord triglyceride concentration needs to be evaluated.©2012, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. All rights reserved.

Item Type: Article
Additional Information: Cited By :16 Export Date: 16 February 2020 Correspondence Address: Ghayour-Mobarhan, M.; Biochemistry of Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; email: ghayourm@mums.ac.ir
Uncontrolled Keywords: antioxidant cord blood lipid profile newborn selenium high density lipoprotein cholesterol lipid low density lipoprotein placebo triacylglycerol adolescent adult article cholesterol blood level clinical evaluation controlled study correlational study double blind procedure drug delivery system drug effect female human lipid analysis lipid blood level normal human prenatal care prenatal exposure randomized controlled trial supplementation triacylglycerol blood level umbilical cord blood Dietary Supplements Fetal Blood Humans Infant, Newborn Lipids Male Pregnancy
Subjects: WQ Obstetrics
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 05 May 2020 03:33
Last Modified: 05 May 2020 03:33
URI: http://eprints.mums.ac.ir/id/eprint/18805

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