Effects of melatonin and theanine administration on pentylenetetrazole-induced seizures and brain tissue oxidative damage in ovariectomized rats

Choopankareh, S. and Vafaee, F. and Shafei, M. N. and Sadeghnia, H. R. and Salarinia, R. and Zarepoor, L. and Hosseini, M. (2015) Effects of melatonin and theanine administration on pentylenetetrazole-induced seizures and brain tissue oxidative damage in ovariectomized rats. Turkish Journal of Medical Sciences, 45 (4). pp. 842-849.

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Background/aim: The effects of coadministration of melatonin and theanine (Mel/Thea) on pentylenetetrazole (PTZ)-induced seizures and brain tissue oxidative damage were investigated in ovariectomized (OVX) and sham-operated rats. Materials and methods: The rats were divided into the following groups: 1) sham, 2) ovariectomized (OVX), 3) sham-PTZ, 4) OVXPTZ, 5) sham-Mel/Thea-PTZ, and 6) OVX-Mel/Thea-PTZ. Groups 1–4 received saline, while groups 5 and 6 received a combination of Mel/Thea for 6 weeks. All animals except for those in groups 1 and 2 received a single injection of PTZ. Results: The OVX-PTZ group had higher generalized tonic-clonic seizure (GTCS) latency compared to the sham-PTZ group. Administration of Mel/Thea increased minimal clonic seizure and GTCS latencies in both the sham-Mel/Thea-PTZ and OVX-Mel/TheaPTZ groups compared to the controls. Additionally, PTZ exposure increased malondialdehyde levels and reduced thiol concentrations in brain tissues of both the sham-PTZ and OVX-PTZ groups. Mel/Thea pretreatment resulted in MDA reduction and thiol increase in brain tissues. Conclusion: The results of this study demonstrated the antioxidant and anticonvulsant activities of Mel/Thea despite the presence or absence of ovarian hormones. © TÜBİTAK.

Item Type: Article
Additional Information: Cited By :6 Export Date: 16 February 2020 CODEN: TJMEE Correspondence Address: Hosseini, M.; Neurocognitive Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical SciencesIran
Uncontrolled Keywords: Brain Melatonin Oxidative stress Pentylenetetrazole Rat Seizures Theanine malonaldehyde pentetrazole thiobarbituric acid reactive substance thiol antioxidant central depressant agent glutamic acid derivative animal experiment animal model animal tissue Article brain cortex brain damage clonic seizure comparative study controlled study experimental behavioral test female hippocampus latent period lipid peroxidation nonhuman ovariectomy oxidation pentylenetetrazole-induced seizure tissue injury tonic clonic seizure animal bioavailability disease model drug effects metabolism Wistar rat Animals Antioxidants Biological Availability Central Nervous System Depressants Disease Models, Animal Glutamates Malondialdehyde Rats Rats, Wistar
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 05 May 2020 06:04
Last Modified: 05 May 2020 06:04
URI: http://eprints.mums.ac.ir/id/eprint/18810

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