Incidence of malignancy after living kidney transplantation: A multicen-ter study from Iran

Einollahi, B. and Rostami, Z. and Nourbala, M. H. and Lessan-Pezeshki, M. and Sim-foroosh, N. and Nemati, E. and Pourfarziani, V. and Beiraghdar, F. and Nafar, M. and Pour-Reza-Gholi, F. and Mazdeh, M. M. and Amini, M. and Ahmadpour, P. and Makhdoomi, K. and Ghafari, A. and Ardalan, M. R. and Khosroshahi, H. T. and Oliaei, F. and Shahidi, S. and Abbaszadeh, S. and Fatahi, M. R. and Hiedari, F. and Makhlogh, A. and Azmandian, J. and Samimagham, H. R. and Shahbazian, H. and Nazemian, F. and Naghibi, M. and Khosravi, M. and Monfared, A. and Mosavi, S. M. and Ahmadi, J. and Jalalzadeh, M. (2012) Incidence of malignancy after living kidney transplantation: A multicen-ter study from Iran. Journal of Cancer, 3 (1). pp. 246-256.

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Abstract

Malignancy is a common complication after renal transplantation. However, limited data are available on post-transplant malignancy in living kidney transplantation. Therefore, we made a plan to evaluate the incidence and types of malignancies, association with the main risk factors and patient survival in a large population of living kidney transplantation. We conducted a large retrospective multicenter study on 12525 renal recipients, accounting for up to 59 of all kidney transplantation in Iran during 22 years follow up period. All information was collected from observation of individual notes or computerized records for transplant patients. Two hundred and sixty-six biopsy-proven malignancies were collected from 16 Transplant Centers in Iran; 26 different type of malignancy categorized in 5 groups were detected. The mean age of patients was 46.2±12.9 years, mean age at tumor diagnosis was 50.8±13.2 years and average time between transplantation and detection of malignancy was 50.0±48.4 months. Overall tumor incidence in recipients was 2. Kaposis' sarcoma was the most common type of tumor. The overall mean survival time was 117.1 months (95 CI: 104.9-129.3). In multivariate analysis, the only independent risk factor associated with mortality was type of malignancy. This study revealed the lowest malignancy incidence in living unrelated kidney transplantation. © Ivyspring International Publisher.

Item Type: Article
Additional Information: Cited By :10 Export Date: 16 February 2020 Correspondence Address: Rostami, Z.; Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Molla Sadra Ave, Vanak Sq. Tehran, Iran; email: rostami@ijnu.ir
Uncontrolled Keywords: Incidence Kidney transplantation Malignancy antineoplastic agent adolescent adult aged article brain cancer cancer incidence cancer mortality cancer prognosis cancer radiotherapy cancer surgery child chondrosarcoma digestive system cancer female follow up graft recipient human human tissue immunosuppressive treatment Iran Kaposi sarcoma living donor lung cancer lymphoproliferative disease male overall survival risk factor school child skin cancer thyroid cancer tumor diagnosis urogenital tract cancer
Subjects: WJ Urogenital System
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 09 May 2020 07:50
Last Modified: 09 May 2020 07:50
URI: http://eprints.mums.ac.ir/id/eprint/18824

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