Investigation of antioxidant and anti-glycation properties of essential oils from fruits and branchlets of Juniperus oblonga

Emami, S. A. and Asgary, S. and Naderi, G. A. and Ardekani, M. R. S. and Aslani, S. and Airin, A. and Kasher, T. and Sahebkar, A. (2012) Investigation of antioxidant and anti-glycation properties of essential oils from fruits and branchlets of Juniperus oblonga. Brazilian Journal of Pharmacognosy, 22 (5). pp. 985-993.

[img] Text
aop03912.pdf

Download (717kB)

Abstract

Plants represent the best and most extensively studied source of natural antioxidants. The present study investigated the antioxidant and anti-glycation properties of different concentrations of essential oils obtained from fruits and branchlets of Juniperus oblonga M. Bieb., Cupressaceae, using different assays. The essential oils were obtained by steam distillation of the branchlets of male tree (BMT), branchlets of female tree (BFT) and fruits of J. oblonga. Compositional analysis of oils was performed using a gas chromatography-mass method. Antioxidant activity was assessed using linoleic acid peroxidation, peroxyl radical mediated hemolysis of red blood cells (RBC) and low-density lipoprotein (LDL) oxidation assays. Anti-glycation properties of oils were evaluated using hemoglobin and insulin glycation assays. Seventeen, eighteen and fifteen compounds were identified in the BMT, BFT and fruit oil, which represented 82.51, 55.69 and 96.89 of the total oils, respectively. α-Pinene was the major component of all three oils. All three oils possessed antioxidant effects against LDL oxidation, linoleic acid peroxidation and peroxyl radical mediated RBC hemolysis. Anti-glycation activities against hemoglobin and insulin glycation were also observed from all tested oils. Overall, there was no unique pattern of dose-dependence for the antioxidant properties of oils in different employed systems. The findings of this study suggest that essential oils from fruits and branchlets of J. oblonga possess antioxidant and anti-glycation properties. Therefore, these oils might be of therapeutic efficacy against diabetes and cardiovascular disease.

Item Type: Article
Additional Information: Cited By :10 Export Date: 16 February 2020 Correspondence Address: Emami, S. A.; Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; email: emamia@mums.ac.ir
Uncontrolled Keywords: Antioxidant Cupressaceae Essential oil Juniperus oblonga Protein glycation hemoglobin insulin linoleic acid low density lipoprotein peroxy radical antioxidant activity article branchlet cell assay controlled study dose response fruit hemolysis human human cell Juniperus lipid peroxidation mass fragmentography oxidation
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 09 May 2020 08:54
Last Modified: 09 May 2020 08:54
URI: http://eprints.mums.ac.ir/id/eprint/18825

Actions (login required)

View Item View Item