The association between oral lichen planus and hepatitis C virus infection; a report from northeast of Iran

Gerayli, S. and Meshkat, Z. and Pasdar, A. and Mozafari, P. M. and Banihashemi, E. and Khajavi, M. A. and Rasekhi, J. (2015) The association between oral lichen planus and hepatitis C virus infection; a report from northeast of Iran. Jundishapur Journal of Microbiology, 8 (4).

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Abstract

Background: The association between hepatitis C virus (HCV) infection and oral lichen planus (OLP) has been the focus of many studies. Fifteen percent of HCV infections lead to sets of extrahepatic manifestations including lichen planus (LP). The prevalence of HCV is heavily influenced by geographical location. Objectives: This study aimed to evaluate the relationship between OLP and HCV infection in Mashhad, northeast of Iran. Materials and Methods: Blood samples were taken from 134 OLP patients and 134 healthy controls (without OLP) to screen for anti-HCV by ELISA (third generation) and reverse transcription polymerase chain reaction (RT-PCR) for HCV-RNA. Results: Of the 134 OLP patients only three (2.23) had HCV infection where both anti-HCV and HCV-RNA were positive. All controls were negative for both anti-HCV and HCV-RNA (P = 0.082). Conclusions: Our investigation illustrated that the prevalence of hepatitis C was higher among OLP patients compared to the control group. These findings are in line with previous results that reported a hepatitis C prevalence of 0.19 among the general population of Mashhad. © 2015, Kowsar Medical Publishing Company. All rights reserved.

Item Type: Article
Additional Information: Cited By :6 Export Date: 16 February 2020 Correspondence Address: Mozafari, P.M.; Oral and Maxillofacial Diseases Research Center, School of Dentistry, Mashhad University of Medical SciencesIran
Uncontrolled Keywords: Anti-HCV Epidemiology HCV-RNA Hepatitis C Iran Lichen planus Oral Viral infections alanine aminotransferase alkaline phosphatase aspartate aminotransferase bilirubin hepatitis C antibody virus RNA adult alanine aminotransferase blood level alkaline phosphatase blood level Article aspartate aminotransferase blood level bilirubin blood level blood sampling clinical feature controlled study disease association disease classification disease duration enzyme linked immunosorbent assay female human incidence major clinical study male prevalence reverse transcription polymerase chain reaction university hospital Hepatitis C virus
Subjects: WU Dentistry. Oral surgery
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 10 May 2020 17:06
Last Modified: 10 May 2020 17:06
URI: http://eprints.mums.ac.ir/id/eprint/18846

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