Thallium exists in opioid poisoned patients

Ghaderi, A. and Vahdati-Mashhadian, N. and Oghabian, Z. and Moradi, V. and Afshari, R. and Mehrpour, O. (2015) Thallium exists in opioid poisoned patients. DARU, Journal of Pharmaceutical Sciences, 23 (1).

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Abstract

Background: Thallium (Tl) is a toxic heavy metal that exists in nature. Tl poisoning (thallotoxicosis) may occur in opioid addicts. This study was designed to evaluate the frequency and level of urinary Tl in opioid abusers. In addition, clinical findings were evaluated. Methods: A total of 150 subjects were examined. Cases with a history of at least 3 years of abuse were admitted in the Imam Reza Hospital as the case group; 50 non-opioid abusers from the target population were included as the control group. Twenty-four hour urinary qualitative and quantitative Tl analyses were performed on both groups. Results: Out of the 150 subjects, 128 (85 ) were negative for qualitative urinary Tl, followed by 5 (trace), 7 (1+), 2 (2+), and 1 (3+). Mean (standard error (SE), Min-Max) quantitative urinary Tl level was 14 μg/L (3.5 μg/L, 0-346 μg/L). Mean urinary Tl level in the case group was 21 μg/L (5 μg/L, 0-346 μg/L) and that in the controls was 1 μg/L (0.14 μg/L, 0-26 μg/L), which were significantly different (P = 0.001). The most frequent clinical findings were ataxia (86 ), sweating (81 ), and constipation (54 ). In all cases (n = 150), the mean (SE) value for cases with positive qualitative urinary Tl was 26.8 μg/L (0.9 μg/L) and that in the negative cases was 2.3 μg/L (0.2 μg/L), which were significantly different (P = 0.002). Conclusions: This study showed that long-term opioid abuse may lead to Tl exposure. In opioid abusers with the clinical manifestation of thallotoxicosis, urinary Tl should be determined. © 2015 Ghaderi et al.

Item Type: Article
Additional Information: Cited By :22 Export Date: 16 February 2020 CODEN: DJTSF Correspondence Address: Afshari, R.; Addiction Research Centre, Mashhad University of Medical Sciences, Imam Reza Hospital, Ibn-e-Sina Street, Iran
Uncontrolled Keywords: Opioid Poisoning Thallium abdominal pain acne adult aged aggression amnesia Article ataxia blurred vision case control study choreoathetosis clinical feature coma constipation controlled study delirium depression diarrhea disease severity dry skin emotionality fatigue female hair loss headache heavy metal poisoning human insomnia major clinical study male nausea opiate addiction paresthesia psychosis qualitative analysis quantitative analysis rash seizure sweating thallotoxicosis tinnitus tremor urinalysis vertigo vomiting weakness adolescent drug contamination middle aged Opioid-Related Disorders urine young adult Case-Control Studies Humans
Subjects: QV pharmacology
W General medicine- Health professions
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 11 May 2020 04:14
Last Modified: 11 May 2020 04:14
URI: http://eprints.mums.ac.ir/id/eprint/18847

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