Oncogenic virus infections in the general population and end-stage renal disease patients with special emphasis on Kaposi’s Sarcoma Associated Herpes Virus (KSHV) in Northeast of Iran

Ghezeldasht, S. A. and Hassannia, T. and Rafatpanah, H. and Hekmat, R. and Valizadeh, N. and Mobarhan, M. G. and Rezaee, S. A. (2015) Oncogenic virus infections in the general population and end-stage renal disease patients with special emphasis on Kaposi’s Sarcoma Associated Herpes Virus (KSHV) in Northeast of Iran. Jundishapur Journal of Microbiology, 8 (3).

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Abstract

Background: Globally, almost 20 of cancers are related to infectious agents that can be prevented. Oncogenicity refers to viruses that may cause cancers, more importantly in immunocompromised subjects such as transplant and hemodialysis patients. Therefore, epidemiological studies are the first line for understanding the importance of these agents in public health, particularly, in mobile populations, tourism and pilgrimage regions. Objectives: Oncogenic viral infections, such as hepatitis B virus (HBV), hepatitis C virus (HCV) and Epstein-barr virus (EBV) are the most common viral agents in immunocompromised patients. Furthermore, human T lymphocyte virus type I (HTLV-I), due to endemicity in Khorasan Razavi province located northeast of Iran as a pilgrimage region, and Kaposi's sarcoma associated herpes virus (KSHV), as an oncogenic herpesvirus in immunocompromised subjects have been investigated among the general population and those with end-stage renal diseases (ESRD). Patients and Methods: A cross-sectional study was carried out among 1227 randomly selected individuals; 25 donors and 195 patients with ESRD, including 60 kidney transplant recipients and 135 dialysis patients from the Khorasan Razavi province, Iran. Serological tests were carried out using commercial enzyme-immunoassay kits. To confirm positive serology tests, the extracted viral DNA or RNA was examined for the presence of KSHV, HTLV-I and HCV by conventional PCR. Results: The prevalence of KSHV infection in the general population was 1.71 (21/1227); 2.60 (10/384) males and 1.30 (11/843) females. In kidney transplants, viral infections occurred in 23.3 of subjects; including EBV, HTLV-I and HBV-HCV co-infection in 8.3, 3.3 and 1.7, respectively. In patients on hemodialysis, viral infections were present in 29.6 including EBV, HTLV-I and HBV-HCV co-infection in 2.2, 5.9 and 16.3, respectively. Seroprevalence of KSHV in patients with kidney transplants was 1.7 and in patients on dialysis was 3.0. Furthermore, KSHV and HTLV-I genome was detected in 25 and 100 of seropositive subjects, respectively. Conclusions: In conclusion, this study demonstrated that these tumor virus infections including HTLV-I, KSHV and particularly hepatitis viruses (HBV plus HCV) are prevalent in the general population and in patients on hemodialysis, which might be an important health concern in this region due to the mobile population. © 2015, Ahvaz Jundishapur University of Medical Sciences.

Item Type: Article
Additional Information: Cited By :5 Export Date: 16 February 2020 Correspondence Address: Rezaee, S.A.; Inflammation and Inflammatory Diseases Research Center, Medical School, Mashhad University of Medical SciencesIran
Uncontrolled Keywords: Chronic HIV seroprevalence HTLV-I infections Human herpesvirus 8 Human kidney transplantation Kidney failure Oncogenic viruses adult Article controlled study cross-sectional study disease association endemic disease Epstein Barr virus Epstein Barr virus infection female graft recipient hemodialysis hepatitis B Hepatitis B virus hepatitis C Hepatitis C virus herpes virus infection Herpesviridae human Human T cell leukemia virus 1 Human T cell leukemia virus infection immunocompromised patient Iran Kaposi sarcoma kidney donor kidney transplantation leukocyte count major clinical study male polymerase chain reaction prevalence renal replacement therapy sex difference treatment duration tumor virus virus infection Human herpesvirus 4 Human T-lymphotropic virus 1
Subjects: WC Communicable Diseases
WJ Urogenital System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 12 May 2020 08:57
Last Modified: 12 May 2020 08:57
URI: http://eprints.mums.ac.ir/id/eprint/18858

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