Preparation, characterization and evaluation of moisturizing and UV protecting effects of topical solid lipid nanoparticles

Golmohammadzadeh, S. and Mokhtari, M. and Jaafari, M. R. (2012) Preparation, characterization and evaluation of moisturizing and UV protecting effects of topical solid lipid nanoparticles. Brazilian Journal of Pharmaceutical Sciences, 48 (4). pp. 683-690.

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Solid lipid nanoparticles (SLN) were recently proposed as carriers for various pharmaceutical and cosmetic actives. These lipid nanoparticles can act as moisturizers and physical sunscreens on their own. Therefore, the full potential of these carriers has yet to be determined. The present study was aimed to determine and compare moisturizing and UV-protecting effects of different solid lipid nanoparticles (SLN) prepared by different solid lipids including Glyceryl monostearate (GMS), Precirol® (P) and cetyl palmitate (CP) as carrier systems of moisturizers and sunscreens. The influence of the size and matrix crystallinity of the solid lipids on the occlusive factor, skin hydration and UV-protection were evaluated by in vitro and in vivo methods. The SLN were prepared by high-shear homogenization and ultrasound methods. Size, zeta potential and morphological characteristics of the samples were assessed by transmission electron microscopy (TEM) and thermotropic properties with differential scanning calorimetry (DSC) technique. Results of the assessments showed that SLN-CP significantly increases skin hydration and UV-protection, compared to SLN-GMS and SLN-P. It was demonstrated that the size of SLN, crystallinity index of solid lipid in SLN and probably other mechanisms besides the occlusive factor can influence skin hydration and UV-protection indices. Furthermore, findings of the assessments demonstrated significant difference between in vitro and in vivo assessments regarding occlusive factor and moisturizing effects. Findings of the present study indicate that the SLN-CP could be a promising carrier for sunscreens and moisturizers.

Item Type: Article
Additional Information: Cited By :13 Export Date: 16 February 2020 Correspondence Address: Golmohammadzadeh, S.; School of Pharmacy, Mashhad University of Medical Sciences, P.O. Box: 91389-13131, Mashhad, Iran; email:
Uncontrolled Keywords: Solid lipid nanoparticles/moisturizing effects Solid lipid nanoparticles/UV protecting cetyl palmitate glycerol palmitostearate glycerol stearate palmitic acid derivative placebo solid lipid nanoparticle sunscreen unclassified drug adult article controlled study crystallization differential scanning calorimetry human human experiment hydration in vitro study in vivo study lipid composition moisture normal human particle size skin protection skin water loss transmission electron microscopy ultraviolet radiation water content zeta potential
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 11 May 2020 07:28
Last Modified: 11 May 2020 07:28

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