Evaluation of Il-6 and high sensitive c reactive protein value in CSF and serum children suspected meningitis referred to pediatric emergency room

Hamedi, A. and Ayatollahi, H. and Nakhaee, A. A. (2012) Evaluation of Il-6 and high sensitive c reactive protein value in CSF and serum children suspected meningitis referred to pediatric emergency room. Iranian Red Crescent Medical Journal, 14 (12).

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Abstract

Background: Acute bacterial meningitis which is a pediatric emergency with high mortality and morbidity must be diagnosed and treat promptly. Often diagnosis of bacterial meningitis from viral meningitis is difficult after some days. Determination of some inflammatory mediators' example IL-6 and HS-CRP were useful in differential diagnosis of bacterial and viral meningitis. Objectives: This study attempted to Determining HS-CRP and IL6 in serum and CSF in children suspected meningitis and Comparing value HS-CRP and IL6 in bacterial/viral meningitis. Patients and Methods: Of children that hospitalized in pediatric emergency ward (Ghaem Hospital Mashhad university of medical science, in duration 01 Dec 2010-01 Dec 2011) and for they performed lumbar puncture, 1cc serum and CSF of they were taken to laboratory and have measured IL-6 with Elisa method and HS-CRP with immunoturbidometry method, patients were followed up and finally we compared levels of this two mediators. Results: Finally, this study performed on 81 children and infants. From 81 cases, 27 cases (33.3) had bacterial meningitis 27 cases (33.3) viral meningitis and 27 cases (33.3) had normal CSF. IL-6 concentration in the CSF and serum were significantly raised in cases of bacterial meningitis (P = 0.001, P = 0.01) but HS-CRP concentration in the CSF and serum were not significantly raised in cases of bacterial meningitis (P = 0.46, P = 0.29). Mean IL-6 concentration in the CSF in bacterial meningitis was (180.74) and in viral meningitis was (39.08).Mean HS-CRP in CSF in bacterial meningitis was (2.22) and viral meningitis was (1.29).Mean HS-CRP in serum in bacterial meningitis was (8.23) and viral meningitis was (6.36). Conclusions: The measurement of IL-6 in the CSF and serum in potentially a very useful diagnostic tool for differential diagnosis of bacterial and viral meningitis.

Item Type: Article
Additional Information: Cited By :5 Export Date: 16 February 2020 Correspondence Address: Hamedi, A.; Mashhad University of Medical Science, Imam Reza Hospital, Mashhad, Iran; email: hamedia@mums.ac.ir
Uncontrolled Keywords: Child Interleukin-6 Meningitis C reactive protein interleukin 6 article bacterial meningitis blood analysis cerebrospinal fluid analysis comparative study differential diagnosis emergency ward enzyme linked immunosorbent assay female follow up human infant lumbar puncture major clinical study male newborn patient referral preschool child turbidimetry virus meningitis
Subjects: WC Communicable Diseases
WS Pediatrics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 06 May 2020 03:27
Last Modified: 06 May 2020 03:27
URI: http://eprints.mums.ac.ir/id/eprint/18869

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