Should guidelines for conventional hemodialysis initiation in acute meth-anol poisoning, be revised, when no fomepizloe is used?

Hekmat, R. and Samini, F. and Dadpour, B. and Maghsudloo, F. and Mojahedi, M. J. (2012) Should guidelines for conventional hemodialysis initiation in acute meth-anol poisoning, be revised, when no fomepizloe is used? Iranian Red Crescent Medical Journal, 14 (11). pp. 754-756.

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Abstract

Background: Consumption of home-distilled alcohol may lead to epidemic or sporadic cases of severe acute methanol poisoning. The difficulty of establishing strict indications for hemodialysis in acute methanol poisoning is a widely recognized issue. Materials and Methods: The determination of the clinical, especially hemodialysis, and Para clinical factors influencing patient survival in 46 acutely methanol poisoned patients was the aim of this cross sectional retrospective study. Clinical and paraclinical variables compared in surviving and non-surviving patients were hemodialysis and ventilation requirements, the level of consciousness, ABG parameters the serum methanol, creatinine and BUN levels. Only ethanol was used for ADH (Alcohol Dehydrogenize) blockade. Results: Receiver operative curve characteristics showed that a serum methanol threshold level of 15mg/dl, instead of 25mg/dl, has a better sensitivity and rather the same specificity for predicting patient mortality. Conclusions: With no fomepizloe and using conventional hemodialysis, lowering the threshold of methanol concentration for hemodialysis initiation, may save lives in acute methanol intoxication. © 2012, Iranian Red Crescent Medical Journal; Published by Kowsar Corp.

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020 Correspondence Address: Hekmat, R.; Department of Nephrology, Ghaem Hospital, Mashhad, Iran; email: drhek-matreza@yahoo.com
Uncontrolled Keywords: Hemodialysis Methanol Poisoning 4 methylpyrazole alcohol alcohol dehydrogenase creatinine acute disease article artificial ventilation blood gas analysis blood level clinical article consciousness creatinine blood level female human male methanol poisoning mortality practice guideline sensitivity and specificity survival urea nitrogen blood level
Subjects: WJ Urogenital System
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 12 May 2020 09:12
Last Modified: 12 May 2020 09:12
URI: http://eprints.mums.ac.ir/id/eprint/18882

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