Ocular abnormalities in multi-transfused beta-thalassemia patients

Jafari, R. and Heydarian, S. and Karami, H. and Shektaei, M. M. and Dailami, K. N. and Amiri, A. A. and Rezaee, M. R. S. and Far, A. A. F. (2015) Ocular abnormalities in multi-transfused beta-thalassemia patients. Indian Journal of Ophthalmology, 63 (9). pp. 710-715.

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Abstract

Aims: The aim of this study was to assess ocular changes in thalassemia patients who have received multiple transfusions and chelate binding therapy in order to avoid iron accumulation. Settings and Design: A cross-sectional study. Subjects and Methods: A total of 54 thalassemia major patients were selected as case group, and 54 age- and sex-matched healthy subjects were regarded as a control group. Ocular examination included visual acuity, refraction testing, slit lamp examination, funduscopy, tonometry, perimetry, tear break-up time test, and color vision testing were performed for all the participants. We computed the frequency and duration of blood transfusion, the mean serum ferritin level, pretransfusion hemoglobin concentration, and type, duration, and daily dose of chelation therapy for thalassemia patients based on their records. Statistical Analysis Used: All data analysis was performed using SPSS, version 19. Results: All the thalassemic patients were asymptomatic, but abnormal ocular findings (dry eye (33.3), cataract (10.2), retinal pigment epithelium degeneration (16.7), color vision deficiency (3.7), and visual field defects (33.7)) were seen in 68.5 of thalassemic group. The prevalence of ocular abnormalities in normal group was 19.4, which was significantly lower than that in thalassemia patients (P = 0.000). No significant correlation was found between ocular abnormalities and mean serum ferritin level (P = 0.627) and mean hemoglobin concentration (P = 0.143). Correlation of number of blood transfusion with the presence of ocular abnormalities was found to be statistically significant (P = 0.005). Conclusions: As life expectancy for beta-thalassemia patients extends, regular ophthalmological evaluation to detect early changes in their ocular system is recommended. © 2015 Indian Journal of Ophthalmology | Published by Wolters Kluwer - Medknow.

Item Type: Article
Additional Information: Cited By :6 Export Date: 16 February 2020 CODEN: IJOMB Correspondence Address: Heydarian, S.; Department of Optometry, School of Paramedical Science, Mashhad University of Medical SciencesIran; email: optheydarian@yahoo.com
Uncontrolled Keywords: Beta-thalassemia major blood transfusion chelation therapy ferritin ocular abnormality chelating agent hemoglobin adolescent adult beta-Thalassemia blood complication cross-sectional study Eye Diseases female human Iran male metabolism ophthalmoscopy prevalence visual acuity young adult Chelating Agents Cross-Sectional Studies Ferritins Hemoglobins Humans
Subjects: WW Ophthalmology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 11 May 2020 08:24
Last Modified: 11 May 2020 08:24
URI: http://eprints.mums.ac.ir/id/eprint/18904

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