Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain

Karimzadeh, F. and Hosseini, M. and Mangeng, D. and Alavi, H. and Hassanzadeh, G. R. and Bayat, M. and Jafarian, M. and Kazemi, H. and Gorji, A. (2012) Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain. BMC Complementary and Alternative Medicine, 12.

[img] Text

Download (2MB)


Background: Essential oil of Pimpinella anisum L. Apiaceae (anise oil) has been widely used in traditional Persian medicine to treat a variety of diseases, including some neurological disorders. This study was aimed to test the possible anti-seizure and anti-hypoxia effects of anise oil.Methods: The effects of different concentrations of anise oil were tested on seizure attacks induced by pentylenetetrazol (PTZ) injection and neuronal hypoxia induced by oxygen withdrawal as well as on production of dark neurons and induction of long-term potentiation (LTP) in in vivo and in vitro experimental models of rat brain.Results: Anise oil significantly prolonged the latency of seizure attacks and reduced the amplitude and duration of epileptiform burst discharges induced by injection of intraperitoneal PTZ. In addition, anise oil significantly inhibited production of dark neurons in different regions of the brain in epileptic rats. Anise oil also significantly enhanced the duration of the appearance of anoxic terminal negativity induced by oxygen withdrawal and inhibited induction of LTP in hippocampal slices.Conclusions: Our data indicate the anticonvulsant and neuroprotective effects of anise oil, likely via inhibition of synaptic plasticity. Further evaluation of anise oil to use in the treatment of neurological disorders is suggested. © 2012 Karimzadeh et al.; licensee BioMed Central Ltd.

Item Type: Article
Additional Information: Cited By :47 Export Date: 16 February 2020 CODEN: BCAMC Correspondence Address: Gorji, A.; Shefa Neuroscience Center, Tehran, Iran; email:
Uncontrolled Keywords: Brain ischemia Cephalic pain Medical plants Stroke Traditional therapy anise oil pentetrazole animal experiment animal model animal tissue anise anticonvulsant activity article brain hypoxia cell hypoxia controlled study drug effect epileptic discharge experimental model hippocampus in vitro study in vivo study latent period long term potentiation male nerve cell nerve cell plasticity neuroprotection nonhuman rat seizure Animals Anoxia Anticonvulsants Brain Long-Term Potentiation Neurons Neuroprotective Agents Oils, Volatile Pentylenetetrazole Phytotherapy Pimpinella Plant Extracts Rats Rats, Wistar Seizures
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 03 May 2020 03:51
Last Modified: 03 May 2020 03:51

Actions (login required)

View Item View Item