Clinical features and drug characteristics of patients with generalized fixed drug eruption in the west of Iran (2005-2014)

Kavoussi, H. and Rezaei, M. and Derakhshandeh, K. and Moradi, A. and Ebrahimi, A. and Rashidian, H. and Kavoussi, R. (2015) Clinical features and drug characteristics of patients with generalized fixed drug eruption in the west of Iran (2005-2014). Dermatology Research and Practice, 2015.

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Background. Generalized fixed drug eruption is a specific variant of fixed drug eruption with multifocal lesions. Diagnosis of this drug reaction is straightforward, but occasionally recognition of the causative drug is not possible. This study was aimed at evaluating the clinical features and culprit drugs in generalized fixed drug eruptions in the west of Iran. Method. This cross-sectional study was carried out on 30 patients with criteria of generalized fixed drug eruption over 9 years. Demographic, clinical, and drug intake information were collected. Results. Out of 30 patients (17 females and 13 males) with the mean age of 26.67 ± 10.21 years, 28 (93.3) and 2 (6.7) cases had plaque and bullous clinical presentation, respectively. Upper limbs were the most common (90) site of involvement. The antibiotic group, especially cotrimoxazole (26.1), was reported to be the most common offending drug, but the causative drug was not determined in 7 (23.3) patients. Conclusion. Many cases of generalized fixed drug eruption firstly presented as limited lesions and led to generalized lesion due to repeated intake of the causative drug. No causative drug was found in some patients, which might be associated with concurrent intake of several drugs, multiple FDE, and peculiarity of the patch test. © 2015 Hossein Kavoussi et al.

Item Type: Article
Additional Information: Cited By :8 Export Date: 16 February 2020 Correspondence Address: Kavoussi, H.; Dermatology Department, Imam Reza Hospital, Kermanshah University of Medical Sciences (KUMS)Iran; email:
Uncontrolled Keywords: cotrimoxazole ibuprofen metronidazole adolescent adult adverse outcome arm disease Article clinical article clinical assessment clinical evaluation clinical feature controlled study cross-sectional study disease association drug use female fixed drug eruption generalized fixed drug eruption human Iran male medical information outcome assessment skin defect vesicular rash
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 03 May 2020 08:02
Last Modified: 03 May 2020 08:02

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