Treatment of cutaneous lesion of 20 years' duration caused by leishmanization

Khamesipour, A. and Abbasi, A. and Firooz, A. and Amin Mohammadi, A. M. and Eskandari, S. E. and Jaafari, M. R. (2012) Treatment of cutaneous lesion of 20 years' duration caused by leishmanization. Indian Journal of Dermatology, 57 (2). pp. 123-125.

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The inoculation of live Leishmania (L.) major to produce a single lesion is called leishmanization (LZ). LZ lesion upon cure prevents further natural infection which might be multiple lesions on unwanted sites such as face. Cutaneous leishmaniasis (CL) usually leads to a self healing lesion; though rarely the lesion persists and becomes refractory to all types of remedies. Here, we present a 41-year-old patient with a 20-year history of cutaneous lesion caused by leishmanization. The causative agent is identified as L. major. The patient did not respond to treatment with meglumine antimoniate, 20 mg/kg/day Sb +5 for three weeks and allopurinol 10 mg/kg for four weeks. After two months, the same treatment was repeated. In addition, a topical liposomal preparation containing 10 paromomycin sulfate was administered twice a day for four weeks. The lesion showed marked improvement during the treatment and was eventually completely healed.

Item Type: Article
Additional Information: Cited By :7 Export Date: 16 February 2020 Correspondence Address: Khamesipour, A.; Center for Research and Training in Skin Diseases and Leprosy, Medical Sciences/University of Tehran, P.O. Box 14155-6383, Tehran 14166, Iran; email:
Uncontrolled Keywords: L. major lesion Leishmanization non-healing paromomycin treatment of cutaneous leishmaniasis allopurinol Leishmania vaccine liposome meglumine antimonate adult amastigote animal experiment animal model article case report disease duration drug treatment failure Euglenozoa follow up healing histopathology human inoculation Leishmania major leishmaniasis liposomal delivery male medical history mouse nonhuman polymerase chain reaction promastigote relapse retreatment skin leishmaniasis treatment duration treatment response
Subjects: WR Dermatology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 11 May 2020 08:50
Last Modified: 11 May 2020 08:50

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