Comparative measurement of ghrelin, leptin, adiponectin, EGF and IGF-1 in breast milk of mothers with overweight/obese and normal-weight infants

Khodabakhshi, A. and Ghayour-Mobarhan, M. and Rooki, H. and Vakili, R. and Hashemy, S. I. and Mirhafez, S. R. and Shakeri, M. T. and Kashanifar, R. and Pourbafarani, R. and Mirzaei, H. and Dahri, M. and Mazidi, M. and Ferns, G. and Safarian, M. (2015) Comparative measurement of ghrelin, leptin, adiponectin, EGF and IGF-1 in breast milk of mothers with overweight/obese and normal-weight infants. European Journal of Clinical Nutrition, 69 (5). pp. 614-618.

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Abstract

Obese infants are more susceptible to develop adulthood obesity and its related comorbidities. Previous studies have shown the presence of hormones and growth factors in maternal breast milk that may influence infant adiposity. The aim of this study was to investigate differences in concentrations of three hormones and two growth factors in the breast milk of mothers with obese and non-obese infants.Subjects/Methods:In this cross-sectional study, 40 mothers with overweight or obese infants (weight for length percentile >97) and 40 age-matched mothers with normal-weight infant (-10<weight for length percentile<85) who were between 2 and 5 months of age were enrolled. Anthropometric indices of infants and mothers were measured by routine methods. Breast milk concentrations of ghrelin and adiponectin, leptin, epithelial growth factor (EGF) and insulin-like growth factor-1 (IGF-1) were measured using enzyme-linked immunosorbent assay methods.Results:The mean breast milk concentration of ghrelin was higher in mothers with normal-weight infants, 137.50 pg/ml, than in mothers with obese infants, 132.00 pg/ml (P=0.001). This was also true regarding the concentration of EGF in mothers with (0/04 ng/ml) and without (0/038 ng/ml) normal-weight infants (P=0.01). No significant differences were observed in concentrations of leptin, adiponectin and IGF-1 between two groups (P>0.05). There was also a significant positive correlation between EGF and ghrelin in both groups.Conclusions:This study revealed that there was a correlation between ghrelin and EGF level in breast milk of mothers with obese and non-obese infants, suggesting a possible regulatory effect of these two hormones on weight in infants. © 2015 Macmillan Publishers Limited.

Item Type: Article
Additional Information: Cited By :19 Export Date: 16 February 2020 CODEN: EJCNE Correspondence Address: Safarian, M.; Department of Nutrition, School of Medicine, Mashhad University of Medical SciencesIran
Uncontrolled Keywords: adiponectin epidermal growth factor ghrelin leptin somatomedin C ADIPOQ protein, human adult age Article birth weight body fat body mass body weight breast milk clinical article comparative study controlled study correlational study cross-sectional study enzyme linked immunosorbent assay female food composition human infant male obesity postnatal growth breast feeding case control study chemistry child development infant nutrition mother Overweight physiology pregnancy young adult Case-Control Studies Cross-Sectional Studies Humans Infant Nutritional Physiological Phenomena Insulin-Like Growth Factor I Milk, Human Mothers
Subjects: WQ Obstetrics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 03 May 2020 08:22
Last Modified: 03 May 2020 08:22
URI: http://eprints.mums.ac.ir/id/eprint/18929

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