Tramadol half life is dose dependent in overdose

Khosrojerdi, H. and Talesh, G. A. and Danaei, G. H. and Saremi, S. S. and Adab, A. and Afshari, R. (2015) Tramadol half life is dose dependent in overdose. DARU, Journal of Pharmaceutical Sciences, 23 (1).

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Abstract

Background: Tramalol overdose is disproportionately more common in Iran. In recent years, Tramadol overdose has become one of the most common causes of poisoning admissions to emergency departments in this country. To the best of our knowledge, there is little or no information regarding the toxicokinetic properties of Tramadol such as its half life. Given the fact that poisoning management should be based on the toxicokinetic of substances, we aimed at investigating the half life of Tramadol in man as a critical toxicokinetic variable in overdose. Methods: Blood samples of each patient were collected on admission and repeated later. Plasma was harvested after separation from blood cells by centrifugation and quantified using HPLC method. Calculations were performed on Tramadol blood concentration quantities. Findings: Demographic: Most of cases were men (81.81). Mean (Standard Deviation (SD), min-max) age was 23 (8.142, 17-40). Serum Tramadol levels: Mean (SD, min-max) first Tramadol concentration was 786.91 (394.53, 391-1495). Mean (SD, min-max) second Tramadol concentration was 433.09 (269.63, 148-950). Mean (SD, min-max) of Tramadol half life was calculated as 9.24 hour (2.310, 4.99-13.45) Associations: Half life was associated with higher concentrations (r=0.708 Sig=0.015). Conclusion: We report the mean half life of tramadol in overdose to be 9.24 hours which is remarkably higher than that measured in previous pharmacokinetic studies. We also concluded that Tramadol half life is dose dependent in overdose which may explain the further consequences of severe overdoses. © 2015 Khosrojerdi et al.

Item Type: Article
Additional Information: Cited By :4 Export Date: 16 February 2020 CODEN: DJTSF Correspondence Address: Afshari, R.; Addiction Research Centre, Imam Reza (p) Hospital, Mashhad University of Medical Sciences, Ibn-e-Sina Street, Iran; email: AfshariR@mums.ac.ir
Uncontrolled Keywords: Half-Life Overdose Toxicokinetic Tramadol narcotic analgesic agent adult Article blood cell blood sampling centrifugation clinical article concentration response cross-sectional study demography disease association dose response drug blood level drug half life drug overdose female high performance liquid chromatography hospital admission human male plasma prospective study toxicokinetics young adult adolescent blood half life time Iran Analgesics, Opioid Cross-Sectional Studies Humans Prospective Studies
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 14 May 2020 16:33
Last Modified: 14 May 2020 16:33
URI: http://eprints.mums.ac.ir/id/eprint/18932

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