Health-related quality of life of breast cancer patients in Iran: Pooled analysis using generalized estimating equations

Kiadaliri, A. A. and Bastani, P. and Ibrahimipour, H. (2012) Health-related quality of life of breast cancer patients in Iran: Pooled analysis using generalized estimating equations. Asian Pacific Journal of Cancer Prevention, 13 (3). pp. 941-944.

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Objective: The aim of current study was to evaluate the changes of health-related quality of life (HRQoL) and its clinical, demographic and socioeconomic determinants during chemotherapy and 4 months follow-up in women with breast cancer using a repeated measures framework. Methods and Materials: A double blind cohort study was performed in 100 breast cancer patients given fluorouracil, doxorubicin and cyclophosphamide (FAC) or docetaxel, doxorubicin, cyclophosphamide (TAC) in south of Iran. HRQoL was assessed at baseline, end of chemotherapy and four months thereafter using the QLQ-C30 questionnaire from European Organization for Research and Treatment of Cancer (EORTC). Generalized estimating equations (GEE) was applied for statistical analysis. Results: The mean of age at baseline was 48.5± 10.6. 70 and 14 of patients were married and smokers, respectively, and 20 suffered from another disease besides breast cancer. The results of GEE showed that after control for baseline scores, the HRQoL significantly improved over time. Although, the patientsin FACgroup had higher scores than the TAC group, the differences also diminished over time. Smoking, marital status andhaving child affected some scales of HRQoL. None of other variables were significantly related to HRQoL. Conclusion: Althoughpatients in TAC groups had lower level of HRQoL over 8 months follow up, they experienced faster improvement than the FAC group. This implies that in long-term, improvements in TAC group are higher than FAC. Having children was positively correlated with HRQoL. Generally, there were no demographic and socio-economic differences in HRQoL in these patients between the chemotherapeutic regimens.

Item Type: Article
Additional Information: Cited By :3 Export Date: 16 February 2020 Correspondence Address: Kiadaliri, A.A.; Division of Health Economics, Department of Clinical Sciences, Lund University, Malmö, Sweden; email:
Uncontrolled Keywords: Breast cancer FAC GEE Iran TAC antineoplastic agent cyclophosphamide doxorubicin fluorouracil adjuvant chemotherapy article breast tumor clinical trial (topic) cohort analysis double blind procedure female health status human middle aged quality of life questionnaire social class treatment outcome Antineoplastic Combined Chemotherapy Protocols Breast Neoplasms Chemotherapy, Adjuvant Clinical Trials as Topic Cohort Studies Double-Blind Method Humans Questionnaires
Subjects: WP Gynecology
QZ pathology-neoplasms-Genetics
Depositing User: mr lib5 lib5
Date Deposited: 09 May 2020 07:09
Last Modified: 09 May 2020 07:09

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