Pentoxifylline in hepatopulmonary syndrome

Kianifar, H. R. and Khalesi, M. and Mahmoodi, E. and Aghaei, M. A. (2012) Pentoxifylline in hepatopulmonary syndrome. World Journal of Gastroenterology, 18 (35). pp. 4912-4916.

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AIM: To determine the effects of pentoxifylline (PTX) on clinical manifestations and evaluate arterial blood gas data in hepatopulmonary syndrome (HPS) in children. METHODS: In a pilot study of 10 children with chronic liver disease, who had HPS, 20 mg/kg/d PTX was administered for 3 mo. Clinical data and arterial blood gas parameters were evaluated at baseline, the end of the treatment period, and 3 mo after drug discontinuation. RESULTS: Six patients could tolerate PTX, while four patients experienced complications. Among patients who could tolerate PTX, there was a significant increase in arterial oxygen pressure (PaO2) (P = 0.02) and oxygen saturation (SaO2) (P = 0.04) and alveolar-arterial oxygen gradient (P = 0.02) after 3 mo of treatment. Significant decreases in PaO2 (P = 0.02) and alveolararterial oxygen gradient (P = 0.02) were also seen after drug discontinuation. CONCLUSION: PTX may improve PaO2, SaO2 and alveolar- arterial oxygen gradient in the early stage of HPS. © 2012 Baishideng.

Item Type: Article
Additional Information: Cited By :13 Export Date: 16 February 2020 CODEN: WJGAF Correspondence Address: Kianifar, H. R.; Allergy Research Center, Ghaem Medical Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 91735, Iran; email:
Uncontrolled Keywords: Alveolararterial oxygen gradient Arterial oxygen pressure Child Hepatopulmonary syndrome Pentoxifylline Therapy adult arterial gas arterial oxygen tension article chronic liver disease clinical article drug induced headache drug tolerability drug withdrawal fatigue female human male nausea oxygen saturation pilot study respiratory tract parameters vomiting Adolescent Blood Gas Analysis Child, Preschool Humans Oxygen Phosphodiesterase 4 Inhibitors Pilot Projects Pulmonary Alveoli Time Factors Treatment Outcome
Subjects: WI Digestive System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 14 May 2020 17:55
Last Modified: 14 May 2020 17:55

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