Species-specific antifungal susceptibility patterns of Scedosporium and Pseudallescheria species

Lackner, M. and De Hoog, G. S. and Verweij, P. E. and Najafzadeh, M. J. and Curfs-Breuker, I. and Klaassen, C. H. and Meis, J. F. (2012) Species-specific antifungal susceptibility patterns of Scedosporium and Pseudallescheria species. Antimicrobial Agents and Chemotherapy, 56 (5). pp. 2635-2642.

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Abstract

Since the separation of Pseudallescheria boydii and P. apiosperma in 2010, limited data on species-specific susceptibility patterns of these and other species of Pseudallescheria and its anamorph Scedosporium have been reported. This study presents the antifungal susceptibility patterns of members affiliated with both entities. Clinical and environmental isolates (n = 332) from a wide range of sources and origins were identified down to species level and tested according to CLSI M38-A2 against eight antifungal compounds. Whereas P. apiosperma (geometric mean MIC/minimal effective concentration MEC values of 0.9, 2.4, 7.4, 16.2, 0.2, 0.8, 1.5, and 6.8 μg/ml for voriconazole, posaconazole, isavuconazole, itraconazole, micafungin, anidulafungin, caspofungin, and amphotericin B, respectively) and P. boydii (geometric mean MIC/MEC values of 0.7, 1.3, 5.7, 13.8, 0.5, 1.4, 2.3, and 11.8 μg/ml for voriconazole, posaconazole, isavuconazole, itraconazole, micafungin, anidulafungin, caspofungin, and amphotericin B, respectively) had similar susceptibility patterns, those for S. aurantiacum, S. prolificans, and S. dehoogii were different from each other. Voriconazole was the only drug with significant activity against S. aurantiacum isolates. The MIC distributions of all drugs except voriconazole did not show a normal distribution and often showed two subpopulations, making a species-based prediction of antifungal susceptibility difficult. Therefore, antifungal susceptibility testing of all clinical isolates remains essential for targeted antifungal therapy. Voriconazole was the only compound with low MIC values (MIC 90 of ≤2 μg/ml) for P. apiosperma and P. boydii. Micafungin and posaconazole showed moderate activity against the majority of Scedosporium strains. Copyright © 2012, American Society for Microbiology. All Rights Reserved.

Item Type: Article
Additional Information: Cited By :139 Export Date: 16 February 2020 CODEN: AMACC Correspondence Address: Meis, J.F.; Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands; email: j.meis@cwz.nl
Uncontrolled Keywords: amphotericin B anidulafungin caspofungin isavuconazole itraconazole micafungin posaconazole voriconazole antifungal activity antifungal susceptibility article Candida parapsilosis concentration response controlled study fungus isolation in vitro study minimum inhibitory concentration nonhuman Petriellidium boydii priority journal Pseudallescheria Pseudallescheria apiosperma Scedosporium Scedosporium aurantiacum Scedosporium dehoogii Scedosporium prolificans species differentiation Amplified Fragment Length Polymorphism Analysis Antifungal Agents Bacterial Typing Techniques Dose-Response Relationship, Drug Drug Resistance, Fungal Echinocandins Humans Lipopeptides Microbial Sensitivity Tests Pyrimidines Species Specificity Triazoles
Subjects: WC Communicable Diseases
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 14 May 2020 17:21
Last Modified: 14 May 2020 17:21
URI: http://eprints.mums.ac.ir/id/eprint/18941

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