Survey of Her2-neu expression and its correlation with histology of gastric carcinoma and gastroesophageal junction adenocarcinoma

Madani, S. H. and Rahmati, A. and Sadeghi, E. and Khazaei, S. and Sadeghi, M. and Payandeh, M. and Amirifard, N. (2015) Survey of Her2-neu expression and its correlation with histology of gastric carcinoma and gastroesophageal junction adenocarcinoma. Asian Pacific Journal of Cancer Prevention, 16 (17). pp. 7755-7758.

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Abstract

Background: There is increasing evidence that HER2-neu is an important biomarker in gastric carcinomas (GC) and gastroesophageal junction (GEJ) adenocarcinomas. The aim of this study was to evaluate HER2-neu expression and also some clinicopathological features of these neoplasms. Materials and Methods: We selected 211 paraffin-embedded blocks, 193 GC and 18 GEJ. Then 4 micron sections were prepared for staining with hematoxylin and eosin and also for IHC (Her2-neu). The Chi-square test was used for significance between expression of HER2-neu and clinicopathological parameters. Results: In patients with advanced cancer of GC and GEJ, HER2-neu overexpression was more associated with the intestinal cancer subtype. Conclusions: This could be a guide to new complementary therapy for affected patients.

Item Type: Article
Additional Information: Cited By :3 Export Date: 16 February 2020 Correspondence Address: Amirifard, N.; Cancer Research Center, Kermanshah University of Medical SciencesIran; email: amirifard.n@gmail.com
Uncontrolled Keywords: Gastric cancer Gastroesophageal cancer Her2-neu IHC epidermal growth factor receptor 2 ERBB2 protein, human tumor marker adenocarcinoma adult aged biosynthesis Esophageal Neoplasms female gastroesophageal junction gene amplification gene expression regulation genetics human intestine tumor male middle aged pathology Stomach Neoplasms very elderly Aged, 80 and over Biomarkers, Tumor Esophagogastric Junction Gene Expression Regulation, Neoplastic Humans Intestinal Neoplasms Receptor, ErbB-2
Subjects: WI Digestive System
QY Clinical Pathology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 14 May 2020 18:39
Last Modified: 14 May 2020 18:39
URI: http://eprints.mums.ac.ir/id/eprint/18946

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