Comparison of intralesional two percent zinc sulfate and glucantime injection in treatment of acute cutaneous leishmaniasis

Maleki, M. and Karimi, G. and Tafaghodi, M. and Raftari, S. and Nahidi, Y. (2012) Comparison of intralesional two percent zinc sulfate and glucantime injection in treatment of acute cutaneous leishmaniasis. Indian Journal of Dermatology, 57 (2). pp. 118-122.

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Cutaneous leishmaniasis is an endemic disease in developing countries caused by different species of leishmania parasite, and if left untreated, it will result in a deformed scar after a relatively long period. Although various systemic and topical treatments have been proposed for leishmaniasis, pentavalent Antimony compounds remain the first-line treatment for it. Considering the cases with treatment failure, potential side effects and reluctance of patients to receive the drug, there are continuing efforts to find better treatment alternatives. Aim: Comparison of the effect of intralesional 2 zinc sulfate injection with Glucantime in treatment of acute cutaneous leishmaniasis. Materials and Methods: In this clinical trial, 45 patients with clinical diagnosis of cutaneous leishmaniasis and positive direct smear for leishman body were treated by intralesional injection of either 2 zinc sulfate or Glucantime. After simple randomization, in one group the patients were treated with 2 bouts of intralesional 2 zinc sulfate with a 2-week interval, and in the other group they were treated with 6 weekly bouts of intralesional Glucantime. The patients were monitored in two week intervals for 8 weeks. Healing of the lesions was evaluated clinically and by direct smear, and the data were analyzed using SPSS (11.5) software, t-Student, Mann-Whitney and Analysis of covariance (ANCOVA) statistical tests. Findings: In the end of study, 34 patients completed the study, 10 of whom received intralesional Glucantime and 24 of whom received intralesional 2 zinc sulfate. The healing rate after 8 weeks was 80 in the group receiving intralesional Glucantime and 33.3 in the one receiving 2 zinc sulfate (P=0.009). Conclusion: Based on the results of this study, intralesional injection of 2 zinc sulfate was less effective in treatment of cutaneous leishmaniasis than intralesional Glucantime.

Item Type: Article
Additional Information: Cited By :8 Export Date: 16 February 2020 Correspondence Address: Nahidi, Y.; Faculty of Medicine, Mashhad University of Medical Sciences, Imam Reza Hospital, Mashhad, Iran; email:
Uncontrolled Keywords: Cutaneous leishmaniasis glucantime intralesional injection treatment zinc sulfate meglumine antimonate adult application site hyperpigmentation article burning sensation child clinical article comparative study controlled study drug efficacy erythema healing human injection site inflammation injection site pain injection site swelling randomized controlled trial school child skin induration skin leishmaniasis skin necrosis treatment response
Subjects: WR Dermatology
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 16 May 2020 11:39
Last Modified: 16 May 2020 11:39

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